ReviewInternational journal of molecular sciences2022
The Impact of Intermittent Hypoxia on Metabolism and Cognition.
Review in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 38 citations in OpenAlex.
- The hypoxic burden algorithm: an integrated index for assessing intermittent hypoxia in pediatric obstructive sleep apnea-a retrospective cohort study.Translational pediatrics · 2026Article
- Cognitive Impairment and Central Sleep Apnea Secondary to Tortuous Vertebral Artery Compression of the Medulla, Mimicking Alzheimer's Disease.Internal medicine (Tokyo, Japan) · 2026Article
- Chronic intermittent hypoxia exacerbates hepatic steatosis in a microbiota-dependent manner in lean mice.mSystems · 2026Article
- Obstructive Sleep Apnea in Patients with Significant Coronary Artery Disease: An Underdiagnosed Condition.Journal of clinical medicine · 2026Article
- Serum Perilipin-2 as a Novel Biomarker for Obstructive Sleep Apnea: Association with Hypoxic Burden and Disease Severity.Journal of clinical medicine · 2026Article
- Enzymatic Biomarkers for Early Diagnosis of Alzheimer's Disease: Uncovering Key Targets and Mechanisms.CNS & neurological disorders drug targets · 2026Review
- Regulatory T cells in hypoxic environments.Frontiers in immunology · 2026Review
- Sleep patterns, genetic factors and the risk of cirrhosis: a prospective cohort study.Human genomics · 2025Article
- Review
- TLR2 and IRF8 are the biomarkers associated with hypoxia in steroid-induced osteonecrosis of the femoral head via bioinformatics analysis and experimental validation.BMC musculoskeletal disorders · 2025Article
- Risk assessment and prevention of cardiovascular events in patients with obstructive sleep apnea syndrome: A narrative review.International journal of cardiology. Cardiovascular risk and prevention · 2025Review
- Obstructive sleep apnea as a predictive indicator for in vitro fertilization and embryo transfer outcomes in patients with polycystic ovary syndrome: a prospective cohort study.Sleep & breathing = Schlaf & Atmung · 2025Observational
- Electroacupuncture mitigates cognitive impairments in chronic hypoxia-induced mice by modulating neuroinflammation.IBRO neuroscience reports · 2025Article
- Association between the non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR) and cognitive impairment in patients with acute mild ischemic stroke.European journal of medical research · 2025Article
- Integrating Mendelian Randomization and Machine Learning to Identify Hypoxia-Related Diagnostic Biomarkers and Causal Relationship in COPD.International journal of chronic obstructive pulmonary disease · 2025Article
- Association between the non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio and cognitive impairment in patients with cerebral small vessel disease.Frontiers in neurology · 2025Article
- Obstructive Sleep Apnea Syndrome: Prediction of Lipid Panel in Relation to Apnea- Hypopnea Index.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2025Article
- TEX10: A Novel Drug Target and Potential Therapeutic Direction for Sleep Apnea Syndrome.Nature and science of sleep · 2025Article
- Differential expression profiles and bioinformatics analysis of microRNAs in brown adipose tissue dysfunction induced by chronic intermittent hypoxia in obstructive sleep apnea.Frontiers in cell and developmental biology · 2025Article
- Clinical characteristics and risk factor analysis of overlapping syndromes of COPD-OSA with metabolic syndrome in middle-to-high altitude areas.Frontiers in medicine · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Intermittent hypoxia (IH), one of the primary pathologies of sleep apnea syndrome (SAS), exposes cells throughout the body to repeated cycles of hypoxia/normoxia that result in oxidative stress and systemic inflammation. Since SAS is epidemiologically strongly correlated with type 2 diabetes/insulin resistance, obesity, hypertension, and dyslipidemia included in metabolic syndrome, the effects of IH on gene expression in the corresponding cells of each organ have been studied intensively to clarify the molecular mechanism of the association between SAS and metabolic syndrome. Dementia has recently been recognized as a serious health problem due to its increasing incidence, and a large body of evidence has shown its strong correlation with SAS and metabolic disorders. In this narrative review, we first outline the effects of IH on the expression of genes related to metabolism in neuronal cells, pancreatic β cells, hepatocytes, adipocytes, myocytes, and renal cells (mainly based on the results of our experiments). Next, we discuss the literature regarding the mechanisms by which metabolic disorders and IH develop dementia to understand how IH directly and indirectly leads to the development of dementia.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.