Evidence map›Paper›PMID 36361732›Full record

SynthesisInternational journal of molecular sciences2022

Genes Whose Gain or Loss of Function Changes Type 1, 2A, 2X, or 2B Muscle Fibre Proportions in Mice-A Systematic Review.

Gabryela Kuhnen, Tiago Guedes Russomanno, Marta Murgia, Nicolas J Pillon, Martin Schönfelder, Henning Wackerhage

Open access · goldAbstract readSystematic Review
In one paragraph

Synthesis in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Mechanisms Underlying the Rarity of Skeletal Muscle Cancers.International journal of molecular sciences · 2024
    Review
  7. Article
  8. Exercise metabolism and adaptation in skeletal muscle.Nature reviews. Molecular cell biology · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 3 countries.

Gabryela KuhnenDepartment of Sports and Health Sciences, Technical University of Munich, 80809 Munich, Germany.ORCID 0000-0001-5440-6610
Tiago Guedes RussomannoDepartment of Sports and Health Sciences, Technical University of Munich, 80809 Munich, Germany.ORCID 0000-0001-8679-3707
Marta MurgiaMax Planck Institute, Martinsried, 82152 Munich, Germany.ORCID 0000-0001-6244-3358
Nicolas J PillonDepartment of Physiology and Pharmacology, Karolinska Institutet, 171 77 Stockholm, Sweden.ORCID 0000-0003-1107-9490
Martin SchönfelderDepartment of Sports and Health Sciences, Technical University of Munich, 80809 Munich, Germany.ORCID 0000-0002-3003-3378
Henning WackerhageDepartment of Sports and Health Sciences, Technical University of Munich, 80809 Munich, Germany.ORCID 0000-0001-5920-5842
Technical University of Munich · DEKarolinska Institutet · SEUniversity of Padua · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Adult skeletal muscle fibres are classified as type 1, 2A, 2X, and 2B. These classifications are based on the expression of the dominant myosin heavy chain isoform. Muscle fibre-specific gene expression and proportions of muscle fibre types change during development and in response to exercise, chronic electrical stimulation, or inactivity. To identify genes whose gain or loss-of-function alters type 1, 2A, 2X, or 2B muscle fibre proportions in mice, we conducted a systematic review of transgenic mouse studies. The systematic review was conducted in accordance with the 2009 PRISMA guidelines and the PICO framework. We identified 25 "muscle fibre genes" (

Indexed as

Muscle Fibers, SkeletalMyosin Heavy ChainsAdultAnimalsElectric StimulationForkhead Transcription FactorsHumansMiceMuscle, SkeletalNuclear Receptor Co-Repressor 1Protein IsoformsRNA-Binding ProteinsForkhead Transcription FactorsFoxJ3 protein, humanMyosin Heavy ChainsNcor1 protein, mouseNuclear Receptor Co-Repressor 1PPARGC1B protein, humanProtein IsoformsRNA-Binding Proteinsmuscle fibre proportionsmyosin heavy chainskeletal muscle fibre

Identifiers

PMID36361732
PMCPMC9658117
OpenAlexW4307280817

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.