ArticleInternational journal of molecular sciences2022
Quetiapine Shortens the Lifespan of
Yizhou Jiang, Uma Gaur, Zhibai Cao, Sheng-Tao Hou, Wenhua Zheng
Open access · goldAbstract read
In one paragraphArticle in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.1field-weighted citation impact, top 62% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed, 1 citations in OpenAlex.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
5 authors at 2 institutions in 2 countries.
Yizhou JiangCentre of Reproduction, Development & Aging and Institute of Translation Medicine, Faculty of Health Sciences, University of Macau, Macau 999078, China.
Uma GaurCentre of Reproduction, Development & Aging and Institute of Translation Medicine, Faculty of Health Sciences, University of Macau, Macau 999078, China.
Zhibai CaoCentre of Reproduction, Development & Aging and Institute of Translation Medicine, Faculty of Health Sciences, University of Macau, Macau 999078, China.
Sheng-Tao HouBrain Research Centre, Department of Biology, School of Life Science, Southern University of Science and Technology, 1088 Xueyuan Blvd, Nanshan District, Shenzhen 518055, China.
Wenhua ZhengCentre of Reproduction, Development & Aging and Institute of Translation Medicine, Faculty of Health Sciences, University of Macau, Macau 999078, China.
University of Macau · MOSouthern University of Science and Technology · CN
Funding
National Natural Science Foundation of China No. 31771128 and 32070969Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions 2020SHIBS0002Shenzhen Science and Technology Innovation Committee Research Grants JCYJ20180504165806229; KQJSCX20180322151111754SUSTech-UQ Joint Center for Neuroscience and Neural Engineering (CNNE)The Science and Technology Development Fund File No. 0127/2019/A3, 0044/2019/AGJ and 0113/2018/A3University of Macau File No. MYRG2018-00134-FHS and MYRG2020-00158-FHS
6 · The paper itselfAbstract
Recent studies implicate a key role of dopamine signaling in lifespan regulation. Our previous study found that quetiapine, an atypical antipsychotic drug that has antagonistic activity on dopamine D2-like receptors (D2Rs), shortened the lifespan of
Indexed as
Caenorhabditis elegansCaenorhabditis elegans ProteinsAnimalsDopamineForkhead Transcription FactorsInsulinLongevityQuetiapine FumarateReceptor, InsulinRibosomal Protein S6 Kinases, 70-kDaCaenorhabditis elegans ProteinsDAF-2 protein, C elegansDopamineForkhead Transcription FactorsInsulinQuetiapine FumarateReceptor, InsulinRibosomal Protein S6 Kinases, 70-kDaRsks-1 protein, C elegansantipsychoticsC. eleganslongevityquetiapine
Identifiers
PMID36361717
PMCPMC9658709
OpenAlexW4307280716
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