Evidence map›Paper›PMID 36361596›Full record

ArticleInternational journal of molecular sciences2022

MGL S3 Chimeric Enzyme Drives Apoptotic Death of EGFR-Dependent Cancer Cells through ERK Downregulation.

Nikolay Bondarev, Karina Ivanenko, Elmira Khabusheva, Timofey Lebedev, Ilya Manukhov, Vladimir Prassolov

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Review
  3. His-tagged pro-apoptotic peptides: enhancing cell internalization and anticancer effect in vitro.Apoptosis : an international journal on programmed cell death · 2025
    Article
  4. Article
  5. Review
  6. Article
  7. Novel Therapeutic Targets for Tumor Microenvironment in Cancer.International journal of molecular sciences · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Nikolay BondarevResearch Center for Molecular Mechanisms of Aging and Age-Related Diseases, Moscow Institute of Physics and Technology, Institutsky Lane 9, 141700 Dolgoprudny, Russia.ORCID 0000-0001-9230-5546
Karina IvanenkoEngelhardt Institute of Molecular Biology, Russian Academy of Sciences, Vavilov Street 32, 119991 Moscow, Russia.ORCID 0000-0001-8496-3338
Elmira KhabushevaEngelhardt Institute of Molecular Biology, Russian Academy of Sciences, Vavilov Street 32, 119991 Moscow, Russia.
Timofey LebedevEngelhardt Institute of Molecular Biology, Russian Academy of Sciences, Vavilov Street 32, 119991 Moscow, Russia.ORCID 0000-0002-5966-0914
Ilya ManukhovResearch Center for Molecular Mechanisms of Aging and Age-Related Diseases, Moscow Institute of Physics and Technology, Institutsky Lane 9, 141700 Dolgoprudny, Russia.
Vladimir PrassolovEngelhardt Institute of Molecular Biology, Russian Academy of Sciences, Vavilov Street 32, 119991 Moscow, Russia.
Engelhardt Institute of Molecular Biology · RUMoscow Institute of Physics and Technology · RU

Funding

Ministry of Science and Higher Education of the Russian Federation agreement 075-03-2022-107, project FSMG-2021-0002Russian Science Foundation 22-14-00353.
6 · The paper itself

Abstract

Methionine dependence of malignant cells is one of the cancer hallmarks. It is well described that methionine deprivation drives cancer cells death, both in vitro and in vivo. Methionine gamma-lyase (MGL) isolated from different species or obtained by genetic engineering can be used for effective methionine depletion. In this work, we show that MGL S3, a genetically engineered protein comprised of MGL from

Indexed as

Antineoplastic AgentsNeuroblastomaCarbon-Sulfur LyasesCell Line, TumorDown-RegulationErbB ReceptorsHumansMethionineRecombinant Fusion ProteinsAntineoplastic AgentsCarbon-Sulfur LyasesEGFR protein, humanErbB ReceptorsL-methionine gamma-lyaseMethionineRecombinant Fusion ProteinsERK signalinggefitinibmethionine

Identifiers

PMID36361596
PMCPMC9657631
OpenAlexW4307270398

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.