Evidence map›Paper›PMID 36361542›Full record

ArticleInternational journal of molecular sciences2022

Plastic and Placenta: Identification of Polyethylene Glycol (PEG) Compounds in the Human Placenta by HPLC-MS/MS System.

Antonio Ragusa, Veronica Lelli, Giuseppina Fanelli, Alessandro Svelato, Sara D'Avino, Federica Gevi, Criselda Santacroce, Piera Catalano, Mauro Ciro Antonio Rongioletti, Caterina De Luca and 3 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 53% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 1 country.

Antonio RagusaDepartment of Obstetrics and Gynecology, Università Campus Bio Medico di Roma, Via Álvaro del Portillo, 21, 00128 Rome, Italy.ORCID 0000-0002-2579-1027
Veronica LelliDepartment of Ecological and Biological Sciences, Università degli Studi della Tuscia, 01100 Viterbo, Italy.
Giuseppina FanelliDepartment of Ecological and Biological Sciences, Università degli Studi della Tuscia, 01100 Viterbo, Italy.ORCID 0000-0002-8423-065X
Alessandro SvelatoDepartment of Obstetrics and Gynecology, Università Campus Bio Medico di Roma, Via Álvaro del Portillo, 21, 00128 Rome, Italy.ORCID 0000-0003-4713-9539
Sara D'AvinoDepartment of Obstetrics and Gynecology, Università Campus Bio Medico di Roma, Via Álvaro del Portillo, 21, 00128 Rome, Italy.
Federica GeviDepartment of Ecological and Biological Sciences, Università degli Studi della Tuscia, 01100 Viterbo, Italy.ORCID 0000-0001-6208-8130
Criselda SantacroceDepartment of Pathological Anatomy, San Giovanni Calibita Fatebenefratelli Hospital, Isola Tiberina, Via di Ponte Quattro Capi, 39, 00186 Roma, Italy.
Piera CatalanoDepartment of Pathological Anatomy, San Giovanni Calibita Fatebenefratelli Hospital, Isola Tiberina, Via di Ponte Quattro Capi, 39, 00186 Roma, Italy.
Mauro Ciro Antonio RongiolettiDepartment of Pathological Anatomy, San Giovanni Calibita Fatebenefratelli Hospital, Isola Tiberina, Via di Ponte Quattro Capi, 39, 00186 Roma, Italy.
Caterina De LucaDepartment of Obstetrics and Gynecology, Università Campus Bio Medico di Roma, Via Álvaro del Portillo, 21, 00128 Rome, Italy.
Alessandra GulottaDepartment of Obstetrics and Gynecology, Università Degli Studi di Sassari, 07100 Sassari, Italy.
Sara RinalducciDepartment of Ecological and Biological Sciences, Università degli Studi della Tuscia, 01100 Viterbo, Italy.
Anna Maria TimperioDepartment of Ecological and Biological Sciences, Università degli Studi della Tuscia, 01100 Viterbo, Italy.ORCID 0000-0001-8457-042X
Università degli Studi della Tuscia · ITUniversità Campus Bio-Medico · ITFatebenefratelli Hospital · ITUniversity of Sassari · IT

Funding

Ministero dell'Istruzione, dell'Università e della Ricerca (MIUR), Rome, Italy. Prot. 2017XCXAFZ
6 · The paper itself

Abstract

The placenta is a crucial interface between the fetus and the maternal environment. It allows for nutrient absorption, thermal regulation, waste elimination, and gas exchange through the mother's blood supply. Furthermore, the placenta determines important adjustments and epigenetic modifications that can change the phenotypic expression of the individual even long after birth. Polyethylene glycol (PEG) is a polyether compound derived from petroleum with many applications, from medicine to industrial manufacturing. In this study, for the first time, an integration of ultra-high-performance liquid chromatography (UHPLC) coupled with mass spectrometry (MS) was used to detect suites of PEG compounds in human placenta samples, collected from 12 placentas, originating from physiological pregnancy. In 10 placentas, we identified fragments of PEG in both chorioamniotic membranes and placental cotyledons, for a total of 36 samples.

Indexed as

PlacentaTandem Mass SpectrometryChromatography, High Pressure LiquidFemaleHumansPlasticsPolyethylene GlycolsPregnancyPlasticsPolyethylene Glycolsplacentaplastics particlespolyethylene glycolUHPLC–mass spectrometry

Identifiers

PMID36361542
PMCPMC9656682
OpenAlexW4307262669

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.