Evidence map›Paper›PMID 36361529›Full record

ArticleInternational journal of molecular sciences2022

Rapid Reversible Osmoregulation of Cytoplasmic Biomolecular Condensates of Human Interferon-α-Induced Antiviral MxA GTPase.

Pravin B Sehgal, Huijuan Yuan, Ye Jin

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Pravin B SehgalDepartment of Cell Biology and Anatomy, New York Medical College, Valhalla, New York, NY 10595, USA.ORCID 0000-0002-9354-9929
Huijuan YuanDepartment of Cell Biology and Anatomy, New York Medical College, Valhalla, New York, NY 10595, USA.
Ye JinDepartment of Cell Biology and Anatomy, New York Medical College, Valhalla, New York, NY 10595, USA.
New York Medical College · US

Funding

New York Medical College none
6 · The paper itself

Abstract

We previously discovered that exogenously expressed GFP-tagged cytoplasmic human myxovirus resistance protein (MxA), a major antiviral effector of Type I and III interferons (IFNs) against several RNA- and DNA-containing viruses, existed in the cytoplasm in phase-separated membraneless biomolecular condensates of varying sizes and shapes with osmotically regulated disassembly and reassembly. In this study we investigated whether cytoplasmic IFN-α-induced

Indexed as

Antiviral AgentsGTP PhosphohydrolasesBiomolecular CondensatesCytoplasmHumansInterferon-alphaMyxovirus Resistance ProteinsOsmoregulationProteinsAntiviral AgentsGTP PhosphohydrolasesInterferon-alphaMyxovirus Resistance ProteinsProteinsantiviral activitybiomolecular condensatesendogenous interferon-α-induced human myxovirus resistance protein (MxA)hypotonic stressliquid-liquid phase separation (LLPS)membraneless organelles (MLOs)osmoregulationSARS-CoV2 virusvacuole-like dilationsvesicular stomatitis virus

Identifiers

PMID36361529
PMCPMC9655878
OpenAlexW4307268228

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.