Evidence map›Paper›PMID 36361307›Full record

ArticleInternational journal of environmental research and public health2022

Nitrate in Maternal Drinking Water during Pregnancy and Measures of Male Fecundity in Adult Sons.

Pernille Jul Clemmensen, Nis Brix, Jörg Schullehner, Anne Gaml-Sørensen, Gunnar Toft, Sandra Søgaard Tøttenborg, Ninna Hinchely Ebdrup, Karin Sørig Hougaard, Birgitte Hansen, Torben Sigsgaard and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of environmental research and public health, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.5field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Perspectives on environment and health research in Denmark.Scandinavian journal of public health · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 1 country.

Pernille Jul ClemmensenDepartment of Public Health, Aarhus University, 8000 Aarhus, Denmark.ORCID 0000-0002-1966-5518
Nis BrixDepartment of Public Health, Aarhus University, 8000 Aarhus, Denmark.ORCID 0000-0002-1499-8401
Jörg SchullehnerDepartment of Public Health, Aarhus University, 8000 Aarhus, Denmark.
Anne Gaml-SørensenDepartment of Public Health, Aarhus University, 8000 Aarhus, Denmark.ORCID 0000-0002-5242-939X
Gunnar ToftSteno Diabetes Center Aarhus, Aarhus University Hospital, 8200 Aarhus, Denmark.
Sandra Søgaard TøttenborgDepartment of Occupational and Environmental Medicine, Copenhagen University Hospital-Bispebjerg and Frederiksberg Hospital, 2400 Copenhagen, Denmark.ORCID 0000-0001-7742-4360
Ninna Hinchely EbdrupFertility Clinic, The Regional Hospital in Horsens, 8700 Horsens, Denmark.ORCID 0000-0002-3330-2203
Karin Sørig HougaardDepartment of Public Health, University of Copenhagen, 1014 Copenhagen, Denmark.ORCID 0000-0002-3386-0512
Birgitte HansenGeological Survey of Denmark and Greenland, 8000 Aarhus, Denmark.ORCID 0000-0003-2318-145X
Torben SigsgaardDepartment of Public Health, Aarhus University, 8000 Aarhus, Denmark.ORCID 0000-0002-2043-7571
Henrik Albert KolstadDepartment of Occupational Medicine, Aarhus University Hospital, 8200 Aarhus, Denmark.
Jens Peter Ellekilde BondeDepartment of Occupational and Environmental Medicine, Copenhagen University Hospital-Bispebjerg and Frederiksberg Hospital, 2400 Copenhagen, Denmark.
Cecilia Høst Ramlau-HansenDepartment of Public Health, Aarhus University, 8000 Aarhus, Denmark.ORCID 0000-0003-3296-0121
Aarhus University · DKUniversity of Copenhagen · DKGeological Survey of Denmark and Greenland · DKRegional Hospital Horsens · DKSteno Diabetes Centers · DK

Funding

Nitrate in drinking water and the risk of adverse birth outcomesR01ES027823 · NIEHS · UNIVERSITY OF ILLINOIS AT CHICAGO · PI STAYNER, LESLIE THOMAS · 2017 to 2020
$1.8M
NIEHS NIH HHS R01 ES027823
6 · The paper itself

Abstract

Animal studies indicate deleterious effects of nitrate exposure on fecundity, but effects in humans are unknown, both for the prenatal and postnatal periods. We aimed to investigate if exposure to nitrate in maternal drinking water during the sensitive period of fetal life is associated with measures of fecundity in the adult sons. In a sub-analysis, the potential effects of nitrate exposure in adulthood were investigated. This cohort included 985 young adult men enrolled in The Fetal Programming of Semen Quality Cohort (FEPOS). Semen characteristics, testes volume and reproductive hormones were analyzed in relation to nitrate concentration in maternal drinking water, using a negative binomial regression model. The nitrate concentration in drinking water was obtained from monitoring data from Danish waterworks that were linked with the mothers' residential address during pregnancy. The median nitrate concentration in maternal drinking water was 2 mg/L. At these low exposure levels, which are far below the World Health Organization's (WHO) guideline value of 50 mg/L, we did not find indications of harmful effects of nitrate on the investigated measures of male fecundity.

Indexed as

Drinking WaterAdultAdult ChildrenFemaleFertilityHumansMaleNitratesNitrogen OxidesOrganic ChemicalsPregnancySemen AnalysisYoung AdultDrinking WaterNitratesNitrogen OxidesOrganic Chemicalsdrinking waternitrateprenatal exposurereproductionsemen analysissemen quality

Identifiers

PMID36361307
PMCPMC9656746
OpenAlexW4308352066

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.