Evidence map›Paper›PMID 36361282›Full record

ArticleInternational journal of environmental research and public health2022

Life-Course Persistent Antisocial Behavior and Accelerated Biological Aging in a Longitudinal Birth Cohort.

Stephanie Langevin, Ashalom Caspi, J C Barnes, Grace Brennan, Richie Poulton, Suzanne C Purdy, Sandhya Ramrakha, Peter T Tanksley, Peter R Thorne, Graham Wilson and 1 more

Open access · goldAbstract read
In one paragraph

Article in International journal of environmental research and public health, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 17 citations in OpenAlex.

  1. Divergent disinhibition profiles linked to externalizing psychopathology.Journal of psychopathology and clinical science · 2026
    Article
  2. Predictions from early adolescent interpersonal aggression to accelerated aging in adulthood: Relational and biological mechanisms of linkage.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2026
    Article
  3. Article
  4. Review
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  9. Biomarkers of aging through the life course: A Recent Literature Update.Current opinion in epidemiology and public health · 2023
    Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 2 countries.

Stephanie LangevinDepartment of Psychology and Neuroscience, Duke University, Durham, NC 27708, USA.ORCID 0000-0001-9154-000X
Ashalom CaspiDepartment of Psychology and Neuroscience, Duke University, Durham, NC 27708, USA.
J C BarnesSchool of Criminal Justice, University of Cincinnati, Cincinnati, OH 45221, USA.
Grace BrennanDepartment of Psychology and Neuroscience, Duke University, Durham, NC 27708, USA.ORCID 0000-0003-0246-0820
Richie PoultonDepartment of Psychology, University of Otago, Dunedin 9016, New Zealand.
Suzanne C PurdyDiscipline of Speech Science, University of Auckland, Auckland 1142, New Zealand.ORCID 0000-0001-9978-8173
Sandhya RamrakhaDepartment of Psychology, University of Otago, Dunedin 9016, New Zealand.
Peter T TanksleyPopulation Research Center, University of Texas at Austin, Austin, TX 78705, USA.
Peter R ThorneDiscipline of Audiology, University of Auckland, Auckland 1142, New Zealand.
Graham WilsonMatai Medical Research Institute, Gisborne 4010, New Zealand.
Terrie E MoffittDepartment of Psychology and Neuroscience, Duke University, Durham, NC 27708, USA.
Duke University · USUniversity of Auckland · NZUniversity of Otago · NZMedical Research Institute of New Zealand · NZThe University of Texas at Austin · USUniversity of Cincinnati · US

Funding

Is mental disorder a preventable cause of age-related disease? The Dunedin Study.R01AG032282 · NIA · DUKE UNIVERSITY · PI CASPI, AVSHALOM, MOFFITT, TERRIE E · 2009 to 2025
$9.5M
Comprehensive portrait of long-term cannabis users: Are they ready for old age?R01AG069939 · NIA · DUKE UNIVERSITY · PI MOFFITT, TERRIE E · 2021 to 2024
$1.3M
Medical Research Council MR/P005918/1NIA NIH HHS R01 AG032282NIA NIH HHS R01 AG069939
6 · The paper itself

Abstract

Prior research shows that individuals who have exhibited antisocial behavior are in poorer health than their same-aged peers. A major driver of poor health is aging itself, yet research has not investigated relationships between offending trajectories and biological aging. We tested the hypothesis that individuals following a life-course persistent (LCP) antisocial trajectory show accelerated aging in midlife. Trajectories of antisocial behavior from age 7 to 26 years were studied in the Dunedin Multidisciplinary Health and Development Study, a population-representative birth cohort (N = 1037). Signs of aging were assessed at age 45 years using previously validated measures including biomarkers, clinical tests, and self-reports. First, we tested whether the association between antisocial behavior trajectories and midlife signs of faster aging represented a decline from initial childhood health. We then tested whether decline was attributable to tobacco smoking, antipsychotic medication use, debilitating illnesses in adulthood, adverse exposures in childhood (maltreatment, socioeconomic disadvantage) and adulthood (incarceration), and to childhood self-control difficulties. Study members with a history of antisocial behavior had a significantly faster pace of biological aging by midlife, and this was most evident among individuals following the LCP trajectory (β, 0.22, 95%CI, 0.14, 0.28,

Indexed as

Antipsychotic AgentsAntisocial Personality DisorderAdolescentAdultAgedAgingBirth CohortHumansLongitudinal StudiesMiddle AgedAntipsychotic Agentsaccelerated agingantisocial trajectoriesbiological agingcrime

Identifiers

PMID36361282
PMCPMC9657643
OpenAlexW4308333920

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.