ArticleInternational journal of environmental research and public health2022
Oral Microcosm Biofilms Grown under Conditions Progressing from Peri-Implant Health, Peri-Implant Mucositis, and Peri-Implantitis.
Article in International journal of environmental research and public health, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed.
- Exploratory randomized trial of Weissella cibaria CMU and oral microbiome changes in peri implant mucositis.Scientific reports · 2026Trial
- The association between Trichomonas tenax and Entamoeba gingivalis and periimplantitis and periodontitis.Clinical oral investigations · 2026Article
- Oral Hygiene and Links to Oral Health of Patients Living in Lithuania and Abroad With an All-On-4 Restoration.Oral health & preventive dentistry · 2026Observational
- The dental implant surface: a review of the past, present and future.Journal of materials science. Materials in medicine · 2026Review
- Advances in oral disease models: a mini-review of developments from 2015 to 2025.Frontiers in dental medicine · 2026Review
- Predictors of implant failure: A comprehensive analysis of risk factors in oral implant restoration for patients with partial defects of dentition.Biomolecules & biomedicine · 2025Article
- Microbial dysbiosis in periodontitis and peri-implantitis: pathogenesis, immune responses, and therapeutic.Frontiers in cellular and infection microbiology · 2025Review
- Assessing peri-implant bacterial community structure: the effect of microbiome sample collection method.BMC oral health · 2024Article
- Development of a Novel Peptide with Antimicrobial and Mineralising Properties for Caries Management.Pharmaceutics · 2023Article
- Evaluating models and assessment techniques for understanding oral biofilm complexity.MicrobiologyOpen · 2023Review
- Article
- How to study biofilms: technological advancements in clinical biofilm research.Frontiers in cellular and infection microbiology · 2023Review
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Peri-implantitis is a disease influenced by dysbiotic microbial communities that play a role in the short- and long-term outcomes of its clinical treatment. The ecological triggers that establish the progression from peri-implant mucositis to peri-implantitis remain unknown. This investigation describes the development of a novel in vitro microcosm biofilm model. Biofilms were grown over 30 days over machined titanium discs in a constant depth film fermentor (CDFF), which was inoculated (I) with pooled human saliva. Following longitudinal biofilm sampling across peri-implant health (PH), peri-implant mucositis (PM), and peri-implantitis (PI) conditions, the characterisation of the biofilms was performed. The biofilm analyses included imaging by confocal laser scanning microscopy (CLSM) and scanning electron microscopy (SEM), selective and non-selective culture media of viable biofilms, and 16S rRNA gene amplification and sequencing. Bacterial qualitative shifts were observed by CLSM and SEM across conditions, which were defined by characteristic phenotypes. A total of 9 phyla, 83 genera, and 156 species were identified throughout the experiment. The phyla
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Registered trials
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