ArticleInternational journal of environmental research and public health2022
Determination of Biological and Molecular Attributes Related to Polystyrene Microplastic-Induced Reproductive Toxicity and Its Reversibility in Male Mice.
Article in International journal of environmental research and public health, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 43 citations in OpenAlex.
- Transcriptomics-Based Evaluation of the Effects of Polyethylene Microplastics onFoods (Basel, Switzerland) · 2025Article
- Endocrine Disrupting Agents: Toxicological Aspects on Male Reproduction.Reproductive sciences (Thousand Oaks, Calif.) · 2025Review
- Melatonin Alleviates the Damage of Polystyrene Microplastics to Porcine Oocytes by Reducing Oxidative Stress and Mitochondrial Damage, and Regulating Autophagy and Apoptosis Levels.Animals : an open access journal from MDPI · 2025Article
- Microplastic exposure induces epithelial barrier alterations and increases collagen deposition in a 3D human endometrial model in vitro.Journal of assisted reproduction and genetics · 2025Article
- Impact of Co-Substrates on the Production of Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) byMaterials (Basel, Switzerland) · 2025Article
- Concerning influences of micro/nano plastics on female reproductive health: focusing on cellular and molecular pathways from animal models to human studies.Reproductive biology and endocrinology : RB&E · 2024Review
- Behavioral Studies of Zebrafish Reveal a New Perspective on the Reproductive Toxicity of Micro- and Nanoplastics.Toxics · 2024Review
- PLASTAMINATION: Outcomes on the Central Nervous System and Reproduction.Current neuropharmacology · 2024Review
- Micro(nano)plastics: an Emerging Burden for Human Health.International journal of biological sciences · 2024Review
- Article
- Microplastics exposure: implications for human fertility, pregnancy and child health.Frontiers in endocrinology · 2023Review
- A short-term high-fat diet alters rat testicular activity and blood-testis barrier integrity through the SIRT1/NRF2/MAPKs signaling pathways.Frontiers in endocrinology · 2023Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Microplastics exist not only in the natural environment, but also in human tissue such as blood and even placenta. Polystyrene microplastic exposure can cause abnormal sperm quality in mice; however, the mechanism is unclear, and whether sperm abnormalities can be restored has not been reported. ICR mice were exposed to 5 μm polystyrene microplastics through the drinking water. After one spermatogenic cycle, mitochondrial damage was observed to explain the possible cause of sperm damage. After 1-2 spermatogenic cycles of recovery, whether the damaged sperm could be recovered was observed. The results show that polystyrene microplastics caused a decrease in the mitochondrial membrane potential, an imbalance of kinetic homeostasis, a change in genetic characteristics, mitophagy, and a decrease in the ATP content in mouse testicular tissue. Oxidative stress may be the cause of mitochondrial damage. After 1-2 spermatogenic cycles, mitochondrial damage was restored and sperm quality was improved. This study explored the mitochondrial causes of reproductive toxicity of polystyrene microplastics and the reversibility of reproductive toxicity, providing data for further research on the toxicity of microplastics and the prevention and treatment of its harm.
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Registered trials
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