Evidence map›Paper›PMID 36360680›Full record

ArticleInternational journal of environmental research and public health2022

Oxidative Stress Responses and Gene Transcription of Mice under Chronic-Exposure to 2,6-Dichlorobenzoquinone.

Wenjing Wu, Yingying Liu, Chunze Li, Fangyu Zhuo, Zexiong Xu, Huachang Hong, Hongjie Sun, Xianfeng Huang, Xinwei Yu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of environmental research and public health, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Chemopreventive Effects ofCurrent issues in molecular biology · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Wenjing WuCollege of Geography and Environmental Science, Zhejiang Normal University, Jinhua 321004, China.
Yingying LiuCollege of Geography and Environmental Science, Zhejiang Normal University, Jinhua 321004, China.
Chunze LiCollege of Geography and Environmental Science, Zhejiang Normal University, Jinhua 321004, China.
Fangyu ZhuoCollege of Geography and Environmental Science, Zhejiang Normal University, Jinhua 321004, China.
Zexiong XuCollege of Geography and Environmental Science, Zhejiang Normal University, Jinhua 321004, China.
Huachang HongCollege of Geography and Environmental Science, Zhejiang Normal University, Jinhua 321004, China.
Hongjie SunCollege of Geography and Environmental Science, Zhejiang Normal University, Jinhua 321004, China.ORCID 0000-0003-0835-5888
Xianfeng HuangNational and Local Joint Engineering Research Center for Ecological Treatment Technology of Urban Water Pollution, College of Life and Environmental Science, Wenzhou University, Wenzhou 325035, China.
Xinwei YuKey Laboratory of Health Risk Factors for Seafood of Zhejiang Province, Zhoushan Municipal Center for Disease Control and Prevention, Zhoushan 316021, China.
Zhejiang Normal University · CNWenzhou University · CNZhejiang Ocean University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

2,6-Dichlorobenzoquinone (2,6-DCBQ), as an emerging disinfection by-production, was frequently detected and identified in the drinking water; however, limited information is available for the toxic effect of 2,6-DCBQ on mice. In the present study, adult mice were used to assess the impact of 2,6-DCBQ via measuring the responses of antioxidant enzymes (superoxide dismutase (SOD) and catalase (CAT)), the key genes (Heme oxygenase-1 (HO-1), NADPH quinone oxidoreductase 1 (NQO1) and glutamate-L-cysteine ligase catalytic subunit (GCLC)) in the Nrf2-keap1 pathway, and lipid peroxidation (malonaldehyde, MDA). Our results clearly indicated that 2,6-DCBQ decreased the activities of SOD and CAT, repressed the transcriptional levels of key genes in Nrf2-keap1 pathway, further caused oxidative damage on mice. These results provided evidence for assessing the threat of 2,6-DCBQ on human.

Indexed as

NF-E2-Related Factor 2Oxidative StressAnimalsAntioxidantsBenzoquinonesHumansKelch-Like ECH-Associated Protein 1MiceSuperoxide DismutaseTranscription, Genetic2,6-dichlorobenzoquinoneAntioxidantsBenzoquinonesKelch-Like ECH-Associated Protein 1NF-E2-Related Factor 2Superoxide Dismutase2,6-dichlorobenzoquinonelipid peroxidationmousemRNA transcriptionNrf2-keap1oxidative stress

Identifiers

PMID36360680
PMCPMC9656914
OpenAlexW4307268354

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.