Evidence map›Paper›PMID 36360310›Full record

ReviewGenes2022

Macrophages at the Crossroad of Meta-Inflammation and Inflammaging.

Lili Qu, Alyssa J Matz, Keaton Karlinsey, Ziming Cao, Anthony T Vella, Beiyan Zhou

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Genes, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Insulin Resistance and Inflammation.International journal of molecular sciences · 2026
    Review
  6. Review
  7. Review
  8. Review
  9. Article
  10. Review
  11. Review
  12. Review
  13. Review
  14. Review
  15. The role of 27-hydroxycholesterol in meta-inflammation.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2024
    Review
  16. Article
  17. Review
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Lili QuDepartment of Immunology, School of Medicine, University of Connecticut, Farmington, CT 06030, USA.ORCID 0000-0002-5253-6742
Alyssa J MatzDepartment of Immunology, School of Medicine, University of Connecticut, Farmington, CT 06030, USA.ORCID 0000-0003-0310-5097
Keaton KarlinseyDepartment of Immunology, School of Medicine, University of Connecticut, Farmington, CT 06030, USA.ORCID 0000-0001-9085-4533
Ziming CaoDepartment of Immunology, School of Medicine, University of Connecticut, Farmington, CT 06030, USA.ORCID 0000-0002-7570-3400
Anthony T VellaDepartment of Immunology, School of Medicine, University of Connecticut, Farmington, CT 06030, USA.
Beiyan ZhouDepartment of Immunology, School of Medicine, University of Connecticut, Farmington, CT 06030, USA.ORCID 0000-0003-0638-2428

Funding

National Institute of Health R01DK121805
6 · The paper itself

Abstract

Macrophages are central players in systemic inflammation associated with obesity and aging, termed meta-inflammation and inflammaging. Activities of macrophages elicited by the two chronic conditions display shared and distinct patterns mechanistically, resulting in multifaceted actions for their pathogenic roles. Drastically expanded tissue macrophage populations under obesity and aging stress attribute to both enhanced recruitment and local expansion. Importantly, molecular networks governing the multifaceted actions of macrophages are directly altered by environmental cues and subsequently contribute to metabolic reprogramming, resulting in meta-inflammation in obesity or inflammaging in aging. In this review, we will summarize how meta-inflammation and inflammaging affect macrophages and the molecular mechanisms involved in these processes.

Indexed as

InflammationMacrophagesAgingHumansLeukocyte CountObesityaginginflammagingmacrophagemeta-inflammationobesity

Identifiers

PMID36360310
PMCPMC9690997

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.