Evidence map›Paper›PMID 36360195›Full record

ArticleGenes2022

What Is the Exact Contribution of

Anna Monica Bianco, Giulia Ragusa, Valentina Di Carlo, Flavio Faletra, Mariateresa Di Stazio, Costantina Racano, Giovanni Trisolino, Stefania Cappellani, Maurizio De Pellegrin, Ignazio d'Addetta and 5 more

Open access · goldAbstract read
In one paragraph

Article in Genes, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Review
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 6 institutions in 1 country.

Anna Monica BiancoGenetics Unit, Institute for Maternal and Child Health, IRCCS "Burlo Garofolo", 34137 Trieste, Italy.ORCID 0000-0001-8101-9659
Giulia RagusaGenetics Unit, Institute for Maternal and Child Health, IRCCS "Burlo Garofolo", 34137 Trieste, Italy.ORCID 0000-0003-3703-5576
Valentina Di CarloUnit of Paediatric Orthopaedic and Traumatology, Institute for Maternal and Child Health, IRCCS "Burlo Garofolo", 34147 Trieste, Italy.
Flavio FaletraGenetics Unit, Institute for Maternal and Child Health, IRCCS "Burlo Garofolo", 34137 Trieste, Italy.ORCID 0000-0003-1483-3612
Mariateresa Di StazioGenetics Unit, Institute for Maternal and Child Health, IRCCS "Burlo Garofolo", 34137 Trieste, Italy.
Costantina RacanoUnit of Pediatric Orthopaedics and Traumatology, Istituto Ortopedico Rizzoli (IRCCS), 40136 Bologna, Italy.
Giovanni TrisolinoUnit of Pediatric Orthopaedics and Traumatology, Istituto Ortopedico Rizzoli (IRCCS), 40136 Bologna, Italy.ORCID 0000-0002-0361-9920
Stefania CappellaniGenetics Unit, Institute for Maternal and Child Health, IRCCS "Burlo Garofolo", 34137 Trieste, Italy.
Maurizio De PellegrinPediatric Orthopedic San Raffaele Hospital of Milano, 20132 Milan, Italy.
Ignazio d'AddettaUnit of Pediatric Orthopaedics and Traumatology Giovanni XXIII Children's Hospital, Via Giovanni Amendola, 70126 Bari, Italy.
Giuseppe CarluccioUnit of Pediatric Orthopaedics and Traumatology Giovanni XXIII Children's Hospital, Via Giovanni Amendola, 70126 Bari, Italy.
Sergio MonfortePediatric Orthopedic of Buzzi Children Hospital of Milano, 20154 Milan, Italy.
Antonio AndreacchioPediatric Orthopedic of Buzzi Children Hospital of Milano, 20154 Milan, Italy.
Daniela DibelloUnit of Pediatric Orthopaedics and Traumatology Giovanni XXIII Children's Hospital, Via Giovanni Amendola, 70126 Bari, Italy.
Adamo P d'AdamoGenetics Unit, Institute for Maternal and Child Health, IRCCS "Burlo Garofolo", 34137 Trieste, Italy.ORCID 0000-0001-9367-4909
IRCCS Materno Infantile Burlo Garofolo · ITOspedale Pediatrico Giovanni XXIII · ITIstituto Ortopedico Rizzoli · ITOspedale dei Bambini Vittore Buzzi · ITUniversity of Trieste · ITVita-Salute San Raffaele University · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Congenital clubfoot is a common pediatric malformation that affects approximately 0.1% of all births. 80% of the cases appear isolated, while 20% can be secondary or associated with complex syndromes. To date, two genes that appear to play an important role are

Indexed as

ClubfootChildDNA Copy Number VariationsHumansMutationPaired Box Transcription FactorsT-Box Domain Proteinshomeobox protein PITX1Paired Box Transcription FactorsT-Box Domain ProteinsTBX4 protein, humanclubfootcongenital malformationcongenital talipes equinovarusPITX1TBX4

Identifiers

PMID36360195
PMCPMC9690101
OpenAlexW4307633312

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.