Evidence map›Paper›PMID 36360183›Full record

ArticleGenes2022

Involvement of NINJ2 Protein in Inflammation and Blood-Brain Barrier Transmigration of Monocytes in Multiple Sclerosis.

Melissa Sorosina, Silvia Peroni, Elisabetta Mascia, Silvia Santoro, Ana Maria Osiceanu, Laura Ferrè, Ferdinando Clarelli, Antonino Giordano, Miryam Cannizzaro, Filippo Martinelli Boneschi and 2 more

Open access · goldAbstract read
In one paragraph

Article in Genes, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Effects ofCell cycle (Georgetown, Tex.) · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Melissa SorosinaLaboratory of Neurological Complex Disorders, Division of Neuroscience, Institute of Experimental Neurology (INSPE), IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.ORCID 0000-0003-4376-2550
Silvia PeroniLaboratory of Neurological Complex Disorders, Division of Neuroscience, Institute of Experimental Neurology (INSPE), IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.
Elisabetta MasciaLaboratory of Neurological Complex Disorders, Division of Neuroscience, Institute of Experimental Neurology (INSPE), IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.
Silvia SantoroLaboratory of Neurological Complex Disorders, Division of Neuroscience, Institute of Experimental Neurology (INSPE), IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.
Ana Maria OsiceanuLaboratory of Neurological Complex Disorders, Division of Neuroscience, Institute of Experimental Neurology (INSPE), IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.
Laura FerrèLaboratory of Neurological Complex Disorders, Division of Neuroscience, Institute of Experimental Neurology (INSPE), IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.
Ferdinando ClarelliLaboratory of Neurological Complex Disorders, Division of Neuroscience, Institute of Experimental Neurology (INSPE), IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.
Antonino GiordanoLaboratory of Neurological Complex Disorders, Division of Neuroscience, Institute of Experimental Neurology (INSPE), IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.
Miryam CannizzaroLaboratory of Neurological Complex Disorders, Division of Neuroscience, Institute of Experimental Neurology (INSPE), IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.
Filippo Martinelli BoneschiNeurology Unit, IRCCS Fondazione Ca' Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy.ORCID 0000-0002-9955-1368
Massimo FilippiNeurology and Neurorehabilitation Unit, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.
Federica EspositoLaboratory of Neurological Complex Disorders, Division of Neuroscience, Institute of Experimental Neurology (INSPE), IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.
Vita-Salute San Raffaele University · ITUniversity of Milan · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Multiple sclerosis (MS) is an inflammatory neurodegenerative disorder of the central nervous system (CNS). The migration of immune cells into the CNS is essential for its development, and plasma membrane molecules play an important role in triggering and maintaining the inflammation. We previously identified ninjurin2, a plasma membrane protein encoded by

Indexed as

Blood-Brain BarrierMultiple SclerosisCell Adhesion Molecules, NeuronalHumansInflammationLipopolysaccharidesMonocytesCell Adhesion Molecules, NeuronalLipopolysaccharidesNINJ2 protein, humaninflammationmultiple sclerosistransmigration

Identifiers

PMID36360183
PMCPMC9690398
OpenAlexW4307237964

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.