Evidence map›Paper›PMID 36360027›Full record

ArticleFoods (Basel, Switzerland)2022

Isorhamnetin Induces Apoptosis and Suppresses Metastasis of Human Endometrial Carcinoma Ishikawa Cells via Endoplasmic Reticulum Stress Promotion and Matrix Metalloproteinase-2/9 Inhibition In Vitro and In Vivo.

Lei Ye, Run-Hui Ma, Xiu-Xiu Zhang, Kiran Thakur, Jian-Guo Zhang, Mohammad Rizwan Khan, Rosa Busquets, Zhao-Jun Wei

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Foods (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 2 pooled it
5.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 2 syntheses or guidelines pooled it, 18 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 3 countries.

Lei YeSchool of Food Science and Biological Engineering, Hefei University of Technology, Hefei 230009, China.
Run-Hui MaSchool of Food Science and Biological Engineering, Hefei University of Technology, Hefei 230009, China.
Xiu-Xiu ZhangSchool of Food Science and Biological Engineering, Hefei University of Technology, Hefei 230009, China.
Kiran ThakurSchool of Food Science and Biological Engineering, Hefei University of Technology, Hefei 230009, China.
Jian-Guo ZhangSchool of Food Science and Biological Engineering, Hefei University of Technology, Hefei 230009, China.
Mohammad Rizwan KhanDepartment of Chemistry, College of Science, King Saud University, Riyadh 11451, Saudi Arabia.ORCID 0000-0001-6270-8539
Rosa BusquetsSchool of Life Sciences, Pharmacy and Chemistry, Kingston University London, London KT1 2EE, UK.ORCID 0000-0001-9033-4757
Zhao-Jun WeiSchool of Food Science and Biological Engineering, Hefei University of Technology, Hefei 230009, China.ORCID 0000-0003-1729-209X
Hefei University of Technology · CNKing Saud University · SAKingston University · GB

Funding

Key research and development projects in Ningxia province 2021BEF02013Major Projects of Science and Technology in Anhui Province 201903a06020021National Natural Science Foundation of Ningxia Province 2021AAC02019Researchers Supporting Project of King Saud University (Riyadh, Saudi Arabia) RSP-2021/138Youth talent cultivation project of North Minzu University 2021KYQD27, FWNX14
6 · The paper itself

Abstract

Endometrial cancer (EC) is a very common female cancer which has attracted more and more attention. According to the individual patient's condition, the current treatment of EC patients is mainly based on surgery, which is supplemented by chemotherapy, radiotherapy, and endocrine intervention. However, these existing treatment strategies also have some inevitable limitations. Therefore, it is particularly important to find an active ingredient with low toxicity and a high safety profile against EC. Isorhamnetin is a flavonoid known to be present in a variety of plants, such as sea buckthorn, dry willow, and wolfberry. In recent years, the anti-tumor effects of isorhamnetin have been reported. In our study, isorhamnetin was shown to induce apoptosis in Ishikawa cells by inducing the endogenous mitochondrial apoptotic pathway and exogenous death receptor pathway, promoting the endoplasmic reticulum stress-related pathway, and activating the corresponding markers of UPR response. In addition, isorhamnetin affected the expression of MMP2 and MMP9-related proteins in vitro and in vivo and eventually repressed metastasis. Therefore, isorhamnetin can be used as a promising medicinal material for the treatment of EC.

Indexed as

endometrial cancerIshikawaisorhamnetinmitochondriaUPR response

Identifiers

PMID36360027
PMCPMC9654916
OpenAlexW4307939228

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.