Evidence map›Paper›PMID 36359894›Full record

ArticleCells2022

Multiplexed Imaging Reveals the Spatial Relationship of the Extracellular Acidity-Targeting pHLIP with Necrosis, Hypoxia, and the Integrin-Targeting cRGD Peptide.

Zhao-Hui Jin, Atsushi B Tsuji, Mélissa Degardin, Pascal Dumy, Didier Boturyn, Tatsuya Higashi

Open access · goldAbstract read
In one paragraph

Article in Cells, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 53% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Zhao-Hui JinDepartment of Molecular Imaging and Theranostics, Institute for Quantum Medical Science, National Institutes for Quantum Science and Technology, Chiba 263-8555, Japan.ORCID 0000-0002-4615-3075
Atsushi B TsujiDepartment of Molecular Imaging and Theranostics, Institute for Quantum Medical Science, National Institutes for Quantum Science and Technology, Chiba 263-8555, Japan.ORCID 0000-0003-2726-288X
Mélissa DegardinDépartement de Chimie Moléculaire, Université Grenoble Alpes, CNRS, 38058 Grenoble, France.
Pascal DumyInstitut des Biomolécules Max Mousseron, École Nationale Supérieure de Chimie de Montpellier, Université de Montpellier, 34000 Montpellier, France.
Didier BoturynDépartement de Chimie Moléculaire, Université Grenoble Alpes, CNRS, 38058 Grenoble, France.
Tatsuya HigashiDepartment of Molecular Imaging and Theranostics, Institute for Quantum Medical Science, National Institutes for Quantum Science and Technology, Chiba 263-8555, Japan.
National Institutes for Quantum Science and Technology · JPCentre National de la Recherche Scientifique · FRÉcole Nationale Supérieure de Chimie de Montpellier · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

pH (low) insertion peptides (pHLIPs) have been developed for cancer imaging and therapy targeting the acidic extracellular microenvironment. However, the characteristics of intratumoral distribution (ITD) of pHLIPs are not yet fully understood. This study aimed to reveal the details of the ITD of pHLIPs and their spatial relationship with other tumor features of concern. The fluorescent dye-labeled pHLIPs were intravenously administered to subcutaneous xenograft mouse models of U87MG and IGR-OV1 expressing α

Indexed as

Fluorescent DyesNeoplasmsAcidsAnimalsHumansHydrogen-Ion ConcentrationHypoxiaIntegrinsMiceNecrosisPeptides, CyclicTumor MicroenvironmentAcidscyclic arginine-glycine-aspartic acid peptideFluorescent DyesIntegrinsPeptides, CycliccRGD peptideintratumoral distributionmultiplexed imagingpHLIPspatial relationshiptumor aciditytumor hypoxiatumor necrosisαVβ3 integrin

Identifiers

PMID36359894
PMCPMC9656628
OpenAlexW4308392459

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.