Evidence map›Paper›PMID 36359884›Full record

ArticleCells2022

Dimethylmyricacene: An In Vitro and In Silico Study of a Semisynthetic Non-Camptothecin Derivative Compound, Targeting Human DNA Topoisomerase 1B.

Alessio Ottaviani, Federico Iacovelli, Joshua Welsch, Blasco Morozzo Della Rocca, Alessandro Desideri, Mattia Falconi, Laurent Calcul, Bill J Baker, Paola Fiorani

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Alessio OttavianiDepartment of Biology, University of Rome Tor Vergata, 00133 Rome, Italy.ORCID 0000-0002-4796-3184
Federico IacovelliDepartment of Biology, University of Rome Tor Vergata, 00133 Rome, Italy.ORCID 0000-0001-7511-6575
Joshua WelschDepartment of Chemistry, University of South Florida, Tampa, FL 33620, USA.
Blasco Morozzo Della RoccaDepartment of Biology, University of Rome Tor Vergata, 00133 Rome, Italy.ORCID 0000-0001-5491-1131
Alessandro DesideriDepartment of Biology, University of Rome Tor Vergata, 00133 Rome, Italy.ORCID 0000-0003-1541-4217
Mattia FalconiDepartment of Biology, University of Rome Tor Vergata, 00133 Rome, Italy.ORCID 0000-0002-3990-4758
Laurent CalculDepartment of Chemistry, University of South Florida, Tampa, FL 33620, USA.
Bill J BakerDepartment of Chemistry, University of South Florida, Tampa, FL 33620, USA.ORCID 0000-0003-3033-5779
Paola FioraniDepartment of Biology, University of Rome Tor Vergata, 00133 Rome, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Human topoisomerase 1B regulates the topological state of supercoiled DNA enabling all fundamental cell processes. This enzyme, which is the unique molecular target of the natural anticancer compound camptothecin, acts by nicking one DNA strand and forming a transient protein-DNA covalent complex. The interaction of human topoisomerase 1B and dimethylmyricacene, a compound prepared semisynthetically from myricanol extracted from

Indexed as

CamptothecinDNA Topoisomerases, Type IDNAHumansMolecular Docking SimulationCamptothecinDNADNA Topoisomerases, Type Idimethylmyricacenehuman topoisomerase 1Bnatural compound inhibition

Identifiers

PMID36359884
PMCPMC9654473

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.