Evidence map›Paper›PMID 36359850›Full record

ReviewCells2022

Enhancing an Oxidative "Trojan Horse" Action of Vitamin C with Arsenic Trioxide for Effective Suppression of KRAS-Mutant Cancers: A Promising Path at the Bedside.

Agata N Burska, Bayansulu Ilyassova, Aruzhan Dildabek, Medina Khamijan, Dinara Begimbetova, Ferdinand Molnár, Dos D Sarbassov

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cells, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Agata N BurskaDepartment of Biology, Nazarbayev University, Astana 010000, Kazakhstan.ORCID 0000-0003-3321-9087
Bayansulu IlyassovaDepartment of Biology, Nazarbayev University, Astana 010000, Kazakhstan.
Aruzhan DildabekDepartment of Biology, Nazarbayev University, Astana 010000, Kazakhstan.
Medina KhamijanDepartment of Biology, Nazarbayev University, Astana 010000, Kazakhstan.
Dinara BegimbetovaNational Laboratory Astana, Nazarbayev University, Astana 010000, Kazakhstan.ORCID 0000-0002-0643-6257
Ferdinand MolnárDepartment of Biology, Nazarbayev University, Astana 010000, Kazakhstan.ORCID 0000-0001-9008-4233
Dos D SarbassovDepartment of Biology, Nazarbayev University, Astana 010000, Kazakhstan.ORCID 0000-0002-6848-1133
Nazarbayev University · KZ

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The turn-on mutations of the

Indexed as

Ascorbic AcidNeoplasmsArsenic TrioxideCell Line, TumorHumansOxidation-ReductionOxidative StressProto-Oncogene Proteins p21(ras)Reactive Oxygen SpeciesVitaminsArsenic TrioxideAscorbic AcidKRAS protein, humanProto-Oncogene Proteins p21(ras)Reactive Oxygen SpeciesVitaminsarsenic trioxide (ATO)Kirsten rat sarcoma (KRAS) mutant ancersoxidative stressreactive oxygen species (ROS)suicidal ROS production by mitochondrial (SRPM)vitamin C (VC also known as ascorbic acid)Warburg effect

Identifiers

PMID36359850
PMCPMC9657932
OpenAlexW4308118686

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.