Evidence map›Paper›PMID 36359787›Full record

ArticleCells2022

Exosomes from Human Omental Adipose-Derived Mesenchymal Stem Cells Secreted into Ascites Promote Peritoneal Metastasis of Epithelial Ovarian Cancer.

Qingxi Qu, Linghong Liu, Yuqian Cui, Yu Chen, Yu Wang, Yaodu Wang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 29 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Qingxi QuDepartment of Obstetrics and Gynecology, Qilu Hospital of Shandong University, Jinan 250012, China.
Linghong LiuResearch Center of Stem Cell and Regenerative Medicine, Shandong University, Jinan 250012, China.
Yuqian CuiDepartment of Obstetrics and Gynecology, Qilu Hospital of Shandong University, Jinan 250012, China.
Yu ChenDepartment of Obstetrics and Gynecology, Qilu Hospital of Shandong University, Jinan 250012, China.
Yu WangDepartment of Obstetrics and Gynecology, Qilu Hospital of Shandong University, Jinan 250012, China.
Yaodu WangDepartment of Radiation Oncology, Qilu Hospital of Shandong University, Jinan 250012, China.
Qilu Hospital of Shandong University · CNShandong University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Epithelial ovarian cancer (EOC) patients frequently develop peritoneal metastasis, especially in the human omentum. However, the mechanism underlying this propensity remains unknown. A previous study found that human omental adipose-derived mesenchymal stem cells are potentially involved in ovarian cancer growth and metastasis, but the results were inconsistent and even contradictory. In addition, the underlying mechanisms of visceral adipose metastasis remain poorly understood. Here, our goal is to clarify the role and mechanism of human omental adipose-derived mesenchymal stem cells (HO-ADSCs) in EOC cancer growth and metastasis. We first found that human omental tissue conditioned medium (HO-CM) enhances EOC cell function. Subsequent coculture studies indicated that HO-ADSCs increase the growth, migratory and invasive capabilities of ovarian cancer cells. Then, we demonstrated that exosomes secreted by HO-ADSCs (HO-ADSC exosomes) enhanced ovarian cancer cell function, and further mechanistic studies showed that the FOXM1, Cyclin F, KIF20A, and MAPK signaling pathways were involved in this process. In addition, subcutaneous tumorigenesis and peritoneal metastatic xenograft experiments provided evidence that HO-ADSC exosomes promote ovarian cancer growth and metastasis in vivo. Finally, our clinical studies provided evidence that ascites from ovarian cancer patients enhance EOC cell line proliferation, migration, and invasion in vitro. The present study indicated that HO-ADSC exosomes are secreted into ascites and exert a tumor-promoting effect on EOC growth and metastasis, providing a new perspective and method to develop future novel therapeutic strategies for the treatment of ovarian cancer.

Indexed as

ExosomesMesenchymal Stem CellsOvarian NeoplasmsPeritoneal NeoplasmsAdipose TissueAscitesCarcinoma, Ovarian EpithelialFemaleHumansNeoplastic ProcessesOmentumADSCs: Adipose-derived mesenchymal stem cellsascitesEOC: Epithelial ovarian cancerepithelial ovarian cancerexosomesexosomes secreted by HO-ADSCs: HO-ADSC exosomesHE: Hematoxylin and eosinHO-ADSC: Human omental Adipose-derived mesenchymal stem cellHO-CM: Human omental tissue conditioned mediumhuman omentumIHC: Immunohistochemistrymesenchymal stem cellsMSC: Mesenchymal stem cellperitoneal metastasisPMX: Peritoneal metastatic xenograftqRT-PCR: Quantitative real-time PCRSBT: Subcutaneous tumorigenesisTEM: Transmission electron microscopy

Identifiers

PMID36359787
PMCPMC9655202
OpenAlexW4307634268

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.