ReviewCells2022
The Role of Crosstalk between Adipose Cells and Myocytes in the Pathogenesis of Sarcopenic Obesity in the Elderly.
Review in Cells, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- Prevalence and Associated Factors of Sarcopenic Obesity in the Community Elderly: Meta-Analysis and Systematic Review.Nutrients · 2026Pooled it
- Extracellular Vesicle-Mediated Local and Systemic Communication in Metabolic Diseases.International journal of molecular sciences · 2026Review
- Association of sarcopenic obesity with advanced cardiovascular-kidney-metabolic syndrome and incident cardiovascular disease: a longitudinal and cross-sectional study.Diabetology & metabolic syndrome · 2026Article
- Age-Stratified Associations of Sarcopenic Obesity With Mortality in Type 2 Diabetes.Journal of cachexia, sarcopenia and muscle · 2026Article
- Visceral-to-peripheral adiposity ratio in proneness to sarcopenic obesity: association with low muscle strength, but not low muscle mass, in young women of South Asian descent.International journal of obesity (2005) · 2026Article
- Adipose-Derived Extracellular Vesicles and Intercellular Crosstalk With Skeletal Muscle: Implications for Sarcopenic Obesity and Metabolic Dysregulation.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2026Review
- Inhibition of TWEAK/Fn14 Ameliorates Sarcopenic Obesity by Restoring Mitochondrial Biogenesis via the AMPK/SIRT1/PGC-1α Axis.Diabetes, metabolic syndrome and obesity : targets and therapy · 2026Article
- Sedentary behavior and type 2 diabetes in community-dwelling middle-aged and older adults: indirect cross-sectional correlation of sarcopenic obesity.Frontiers in endocrinology · 2026Article
- Correlation of sarcopenic obesity with mild cognitive impairment in middle-aged and older adults: a prospective cohort study based on the nationwide longitudinal survey of CHARLS.Diabetology & metabolic syndrome · 2025Article
- Biological organ ages associate with risk of chronic diseases in a community-based population.JCI insight · 2025Article
- Association and discriminative performance of relative fat mass for frailty index in US older adultsoxy_comment_end.Scientific reports · 2025Article
- The Prevalence of and Factors Associated with Sarcopenic Obesity, Sarcopenia, and Obesity Among Korean Adults: Findings from the 2022-2023 Korea National Health and Nutrition Examination Survey.Medicina (Kaunas, Lithuania) · 2025Article
- Central and peripheral arterial stiffness and sarcopenia in hospitalized older adults.Aging clinical and experimental research · 2025Article
- Associations Between Adherence to the Mediterranean Diet and Incident Sarcopenia in Prospective Cohort Studies.Nutrients · 2025Review
- Circulating Muscle Markers for Sarcopenia in Peritoneal Dialysis.International journal of nephrology · 2025Review
- Association between sarcopenic obesity and cardiovascular diseases: the role of systemic inflammation indices.Frontiers in medicine · 2025Article
- Unraveling the metabolic pathways between atherosclerosis and sarcopenia.Frontiers in endocrinology · 2025Review
- Overlap between body composition abnormalities and sex-specific prognostication in decompensated cirrhosis.Frontiers in nutrition · 2025Article
- Impact of Adipose Tissue and Lipids on Skeletal Muscle in Sarcopenia.Journal of cachexia, sarcopenia and muscle · 2025Review
- Can simple measures from clinical practice serve as a proxy for sarcopenic obesity and identify mortality risk?Aging clinical and experimental research · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
As a result of aging, body composition changes, with a decline in muscle mass and an increase in adipose tissue (AT), which reallocates from subcutaneous to visceral depots and stores ectopically in the liver, heart and muscles. Furthermore, with aging, muscle and AT, both of which have recognized endocrine activity, become dysfunctional and contribute, in the case of positive energy balance, to the development of sarcopenic obesity (SO). SO is defined as the co-existence of excess adiposity and low muscle mass and function, and its prevalence increases with age. SO is strongly associated with greater morbidity and mortality. The pathogenesis of SO is complex and multifactorial. This review focuses mainly on the role of crosstalk between age-related dysfunctional adipose and muscle cells as one of the mechanisms leading to SO. A better understanding of this mechanisms may be useful for development of prevention strategies and treatments aimed at reducing the occurrence of SO.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.