Evidence map›Paper›PMID 36359530›Full record

ArticleDiagnostics (Basel, Switzerland)2022

CD8 Encephalitis: A Diagnostic Dilemma.

Rohan Sharma, Thomas Spradley, Morgan Campbell, Shubham Biyani, Pulkit Singhal, Hisham Elkhider, Krishna Nalleballe, Murat Gokden, Manoj Kumar, Nidhi Kapoor

Open access · goldAbstract readCase Reports
In one paragraph

Article in Diagnostics (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.4field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Glutathione in HIV-Associated Neurocognitive Disorders.Current issues in molecular biology · 2024
    Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Rohan SharmaDepartment of Neurocritical Care, Mayo Clinic in Florida, Jacksonville, FL 32224, USA.ORCID 0000-0002-3005-1867
Thomas SpradleyDepartment of Medicine, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.
Morgan CampbellCollege of Medicine, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.
Shubham BiyaniDepartment of Neurology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.
Pulkit SinghalCollege of Osteopathic Medicine, California Health Sciences University, Clovis, CA 93612, USA.
Hisham ElkhiderDepartment of Neurology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.
Krishna NalleballeDepartment of Neurology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.ORCID 0000-0003-4943-171X
Murat GokdenDepartment of Pathology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.
Manoj KumarDepartment of Radiology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.
Nidhi KapoorDepartment of Neurology, Baptist Medical Center, Jacksonville, FL 32207, USA.
University of Arkansas for Medical Sciences · USBaptist Medical Center Jacksonville · USMayo Clinic in Florida · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

CD8+ encephalitis is a subacute encephalopathy associated with HIV infection. Pathophysiology is thought to be auto-reactive CD8+ cells attacking on HIV infected CD4+ cells and 'viral escape' phenomena (replication of CD8+ cells in CSF). We present a case of a 45-year-old man with well controlled HIV who developed CD8 encephalitis following Herpes simplex encephalitis. He had persistent encephalopathy for several weeks with status epilepticus and agitated delirium, and diagnosis remained elusive until a brain biopsy confirmed the diagnosis.

Indexed as

CD8 encephalitisencephalitisHIVHSV

Identifiers

PMID36359530
PMCPMC9689240
OpenAlexW4308334219

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.