Evidence map›Paper›PMID 36359498›Full record

ReviewDiagnostics (Basel, Switzerland)2022

Lymphocyte-to-Monocyte Ratio and Clinical Outcomes in Cholangiocarcinoma: A Systematic Review and Meta-Analysis.

Giuseppe Dotto-Vasquez, Andrea K Villacorta-Ampuero, Juan R Ulloque-Badaracco, Enrique A Hernandez-Bustamante, Esteban A Alarcón-Braga, Percy Herrera-Añazco, Vicente A Benites-Zapata, Adrian V Hernandez

Abstract readReview
In one paragraph

Review in Diagnostics (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Giuseppe Dotto-VasquezEscuela de Medicina, Universidad Peruana de Ciencias Aplicadas, Lima 15023, Peru.
Andrea K Villacorta-AmpueroEscuela de Medicina, Universidad Peruana de Ciencias Aplicadas, Lima 15023, Peru.
Juan R Ulloque-BadaraccoEscuela de Medicina, Universidad Peruana de Ciencias Aplicadas, Lima 15023, Peru.ORCID 0000-0002-1093-4937
Enrique A Hernandez-BustamanteSociedad Científica de Estudiantes de Medicina de la Universidad Nacional de Trujillo, Trujillo 13011, Peru.ORCID 0000-0002-1974-5200
Esteban A Alarcón-BragaEscuela de Medicina, Universidad Peruana de Ciencias Aplicadas, Lima 15023, Peru.
Percy Herrera-AñazcoEscuela de Enfermería, Universidad Privada San Juan Bautista, Lima 15067, Peru.ORCID 0000-0003-0282-6634
Vicente A Benites-ZapataUnidad de Investigación para la Generación y Síntesis de Evidencias en Salud, Vicerrectorado de Investigación, Universidad San Ignacio de Loyola, Lima 14072, Peru.
Adrian V HernandezUnidad de Revisiones Sistemáticas y Meta-análisis, Guías de Práctica Clínica y Evaluaciones de Tecnología Sanitaria, Vicerrectorado de Investigación, Universidad San Ignacio de Loyola, Lima 15012, Peru.ORCID 0000-0002-9999-4003

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lymphocyte-to-Monocyte ratio (LMR) has shown an association with survival outcomes in several oncological diseases. This study aimed to evaluate the association between LMR and clinical outcomes for cholangiocarcinoma patients. A systematic review and meta-analysis were performed to assess the association between LMR values and overall survival (OS), disease-free survival (DFS), recurrence-free survival (RFS) and time to recurrence (TTR) in cholangiocarcinoma patients. We used Hazard ratio (HR) and their 95% confidence interval (CI) as a measure of effect for the random effect model meta-analysis. The Newcastle-Ottawa Scale was used for quality assessment. The Egger test and funnel plot were developed for approaching publication bias. A total of 19 studies were included in this study (n = 3860). The meta-analysis showed that cholangiocarcinoma patients with low values of LMR were associated with worse OS (HR: 0.82; 95% CI: 0.71-0.96; I

Indexed as

cholangiocarcinomalymphocyte–monocyte ratiometa-analysissurvival

Identifiers

PMID36359498
PMCPMC9689307

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.