Evidence map›Paper›PMID 36359362›Full record

ArticleBiomedicines2022

Whole Exome Sequencing Identifies PHF14 Mutations in Neurocytoma and Predicts Responsivity to the PDGFR Inhibitor Sunitinib.

Dongyun Zhang, William Yong, Masoud Movassaghi, Fausto J Rodriguez, Issac Yang, Paul McKeever, Jiang Qian, Jian Yi Li, Qinwen Mao, Kathy L Newell and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedicines, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 8 institutions in 1 country.

Dongyun ZhangDepartment of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.ORCID 0000-0002-0751-7809
William YongDepartment of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.
Masoud MovassaghiDepartment of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.
Fausto J RodriguezDepartment of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.ORCID 0000-0001-8662-1219
Issac YangDepartment of Neurosurgery, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.
Paul McKeeverDepartment of Pathology and Clinical Laboratories, University of Michigan, Ann Arbor, MI 48109, USA.
Jiang QianDepartment of Pathology, Albany Medical Center, Albany, NY 12208, USA.
Jian Yi LiDepartment of Pathology and Laboratory Medicine, North Shore University Hospital and Long Island Jewish Medical Center, Manhasset, NY 11040, USA.
Qinwen MaoDepartment of Pathology, University of Utah, Salt Lake City, UT 84112, USA
Kathy L NewellDepartment of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Richard M GreenNeuro-Oncology Program, Kaiser Los Angeles Medical Center, Los Angeles, CA 90027, USA.
Cynthia T WelshDepartment of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, SC 29425, USA.
Anthony P HeaneyDepartment of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.
University of California, Los Angeles · USAlbany Medical Center Hospital · USIndiana University School of MedicineLos Angeles Medical Center · USMedical University of South Carolina · USNorthwell Health · USUniversity of Michigan · USUniversity of Utah · US

Funding

UCLA SPORE in Brain CancerP50CA211015 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI David A. Nathanson · 2017 to 2026
$25.2M
NCI NIH HHS P50 CA211015
6 · The paper itself

Abstract

Neurocytomas are rare low-grade brain tumors predominantly affecting young adults, but their cellular origin and molecular pathogenesis is largely unknown. We previously reported a sellar neurocytoma that secreted excess arginine vasopressin causing syndrome of inappropriate anti-diuretic hormone (SIADH). Whole exome sequencing in 21 neurocytoma tumor tissues identified somatic mutations in the

Indexed as

neurocytomaplant homeodomain finger protein 14 (PHF14)platelet derived growth factor receptor-alpha (PDGFRα)Sunitinibwhole exome sequencing (WES)

Identifiers

PMID36359362
PMCPMC9687778
OpenAlexW4308531562

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.