Evidence map›Paper›PMID 36359335›Full record

ArticleBiomedicines2022

Urinary Bladder Patch Made with Decellularized Vein Scaffold Seeded with Adipose-Derived Mesenchymal Stem Cells: Model in Rabbits.

Tadeu Ravazi Piovesana, Lenize da Silva Rodrigues, Ana Livia de Carvalho Bovolato, Diego Noé Rodríguez-Sánchez, Jaqueline Carvalho Rinaldi, Nilton José Santos, Julia Calvi Mori, Pedro Luiz Toledo de Arruda Lourenção, Lynn Birch, Matheus Bertanha

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedicines, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Tadeu Ravazi PiovesanaDepartment of Surgery and Orthopedics, Botucatu Medical School, São Paulo State University-UNESP, Botucatu 18618-687, Brazil.
Lenize da Silva RodriguesDepartment of Surgery and Orthopedics, Botucatu Medical School, São Paulo State University-UNESP, Botucatu 18618-687, Brazil.ORCID 0000-0001-7972-8472
Ana Livia de Carvalho BovolatoApplied Biotechnology Laboratory, Clinical Hospital of Botucatu Medical School, São Paulo State University-UNESP, Botucatu 18618-687, Brazil.ORCID 0000-0003-0245-122X
Diego Noé Rodríguez-SánchezApplied Biotechnology Laboratory, Clinical Hospital of Botucatu Medical School, São Paulo State University-UNESP, Botucatu 18618-687, Brazil.ORCID 0000-0001-6524-5939
Jaqueline Carvalho RinaldiPostgraduate Program in Biosciences and Physiopathology, State University of Maringa, Maringá 87020-900, Brazil.ORCID 0000-0002-1736-5984
Nilton José SantosDepartment of Structural and Functional Biology, Institute of Bioscience of Botucatu, São Paulo State University-UNESP, Botucatu 18618-687, Brazil.ORCID 0000-0002-8549-7436
Julia Calvi MoriPostgraduate Program in Biosciences and Physiopathology, State University of Maringa, Maringá 87020-900, Brazil.
Pedro Luiz Toledo de Arruda LourençãoDepartment of Surgery and Orthopedics, Botucatu Medical School, São Paulo State University-UNESP, Botucatu 18618-687, Brazil.
Lynn BirchDepartment of Urology, College of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA.ORCID 0000-0003-1153-625X
Matheus BertanhaDepartment of Surgery and Orthopedics, Botucatu Medical School, São Paulo State University-UNESP, Botucatu 18618-687, Brazil.ORCID 0000-0002-6851-2841
Universidade Estadual Paulista (Unesp) · BRUniversidade Estadual de Maringá · BRUniversidade Estadual de Campinas (UNICAMP) · BRUniversity of Illinois Chicago · US

Funding

São Paulo Research Foundation 2017/12292-7
6 · The paper itself

Abstract

backgroundTo evaluate tissue regeneration of the urinary bladder after the implantation of a decellularized vein sown with autologous adipose-derived mesenchymal stem cells (ASC) on luminal surfaces.

methodsNew Zealand rabbits (

resultsThe integrity of the urinary bladder was maintained in both groups. A superior regenerative process was observed in the G2 group, compared to the G1 group. We observed a greater urothelial epithelialization and maturity of the mucosa and submucosa fibroblasts. Furthermore, SEM demonstrated a notable amount of urothelial villus in the G2 group.

conclusionDecellularized vena cava scaffolds were able to maintain the integrity of the urinary bladder in the proposed model. In addition, ASCs accelerated the regenerative process development, observed primarily by the new urothelial epithelization and the maturity of mucosa and submucosa fibroblasts.

Indexed as

mesenchymal stem celltissue engineeringurinary bladderurinary bladder diseasesurologic surgical procedures

Identifiers

PMID36359335
PMCPMC9687924
OpenAlexW4308391443

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.