Evidence map›Paper›PMID 36359289›Full record

ArticleBiomedicines2022

Orthostatic Challenge-Induced Coagulation Activation in Young and Older Persons.

Axel Schlagenhauf, Bianca Steuber, Markus Kneihsl, Thomas Gattringer, Martin Koestenberger, Melina Tsiountsioura, Tobias Ziegler, Erwin Tafeit, Margret Paar, Willibald Wonisch and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedicines, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 1 institution in 1 country.

Axel SchlagenhaufDepartment of Paediatrics and Adolescent Medicine, Division of General Paediatrics, Medical University of Graz, 8036 Graz, Austria.
Bianca SteuberOtto Loewi Research Centre, Division of Physiology, Medical University of Graz, 8010 Graz, Austria.ORCID 0000-0002-7308-5450
Markus KneihslDepartment of Neurology, Medical University of Graz, 8036 Graz, Austria.
Thomas GattringerDepartment of Neurology, Medical University of Graz, 8036 Graz, Austria.
Martin KoestenbergerDepartment of Paediatrics and Adolescent Medicine, Division of General Paediatrics, Medical University of Graz, 8036 Graz, Austria.ORCID 0000-0003-1766-7859
Melina TsiountsiouraOtto Loewi Research Centre, Division of Medicinal Chemistry, Medical University of Graz, 8010 Graz, Austria.
Tobias ZieglerOtto Loewi Research Centre, Division of Medicinal Chemistry, Medical University of Graz, 8010 Graz, Austria.
Erwin TafeitOtto Loewi Research Centre, Division of Medicinal Chemistry, Medical University of Graz, 8010 Graz, Austria.
Margret PaarOtto Loewi Research Centre, Division of Medicinal Chemistry, Medical University of Graz, 8010 Graz, Austria.ORCID 0000-0001-5494-8890
Willibald WonischOtto Loewi Research Centre, Division of Medicinal Chemistry, Medical University of Graz, 8010 Graz, Austria.ORCID 0000-0001-7171-9539
Thomas WagnerDepartment of Blood Group Serology and Transfusion Medicine, Medical University of Graz, 8036 Graz, Austria.
Andreas RösslerOtto Loewi Research Centre, Division of Physiology, Medical University of Graz, 8010 Graz, Austria.ORCID 0000-0001-9543-8870
James Elvis WahaGeneral, Visceral and Transplant Surgery, Department of Surgery, Medical University of Graz, 8036 Graz, Austria.
Gerhard CvirnOtto Loewi Research Centre, Division of Medicinal Chemistry, Medical University of Graz, 8010 Graz, Austria.ORCID 0000-0002-1410-1844
Nandu GoswamiOtto Loewi Research Centre, Division of Physiology, Medical University of Graz, 8010 Graz, Austria.ORCID 0000-0002-6704-0723
Medical University of Graz · AT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The incidence of thrombosis increases with aging. We investigated the coagulatory/haemostatic system across the ages and tested the hypothesis that older persons have a hypercoagulable state compared to younger persons at rest, and that standing up (orthostasis) leads to greater changes in coagulation in older persons. In total, 22 older and 20 young participants performed a 6 min sit-to-stand test (orthostatic challenge). Blood was collected prior to and at the end of standing and haemostatic profiling was performed via thrombelastometry (TEM), calibrated automated thrombogram (CAT) and standard coagulation assays. At baseline, three CAT-derived values indicated enhanced capability to generate thrombin in older participants. However, other measured parameters did not suggest a hypercoagulable state in older participants: prolonged TEM-derived coagulation times (295 vs. 209 s, medians,

Indexed as

agingclot formationorthostatic challengethrombelastometrythrombin generationthrombosis

Identifiers

PMID36359289
PMCPMC9687232
OpenAlexW4308121377

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.