ReviewBiomedicines2022
Obstructive Sleep Apnoea and Lipid Metabolism: The Summary of Evidence and Future Perspectives in the Pathophysiology of OSA-Associated Dyslipidaemia.
Review in Biomedicines, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
50 citing papers in PubMed, 1 synthesis or guideline pooled it, 69 citations in OpenAlex.
- Association between atherogenic index of plasma and various metabolic conditions: an umbrella review on meta-analyses.BMC cardiovascular disorders · 2025Pooled it
- Intermittent hypoxia increases lipid insulin resistance in healthy humans: A randomized crossover trial.Journal of sleep research · 2025Trial
- Association between ln(FPG/HDL-C) × BMI and self-reported obstructive sleep apnea: A cross-sectional study using NHANES data.Medicine · 2026Article
- Effects of nocturnal intermittent hypoxia on metabolic syndrome in Japanese adults without abdominal obesity.International journal of obesity (2005) · 2026Article
- Peripheral Mononuclear Cells Metabolomics in Obstructive Sleep Apnea Syndrome (OSAS): An Exploratory Pilot Study of Immunometabolic Signatures.International journal of molecular sciences · 2026Article
- Excessive Daytime Sleepiness, but Not Insomnia Is Associated With Dyslipidaemia in Patients With Obstructive Sleep Apnoea Participating in ESADA.Journal of sleep research · 2026Article
- The Association of Remnant Cholesterol with Obstructive Sleep Apnea and Coronary Heart Disease: A Cross-Sectional Study.Vascular health and risk management · 2026Article
- Association between minimum nocturnal heart rate and cerebral small vessel disease in patients with obstructive sleep apnea.Frontiers in aging neuroscience · 2026Article
- Dose-dependent vitamin D3 supplementation attenuates endothelial dysfunction and renal injury in an obstructive sleep apnea rat model.Frontiers in pharmacology · 2026Article
- Association of follicle-stimulating hormone with dyslipidaemia in men with obstructive sleep apnoea.Annals of medicine · 2025Article
- Circulating oxylipins predict mortality in heart failure with preserved ejection fraction.ESC heart failure · 2025Observational
- Interactions between lipid droplets and mitochondria in metabolic diseases.Lipids in health and disease · 2025Review
- The Relationship Between Cardiac Syndrome X and Obstructive Sleep Apnea and the Effects of Sleep Apnea Treatment on Myocardial Ischemia.Journal of clinical medicine · 2025Article
- Role of Free Radicals in the Pathophysiology of OSA: A Narrative Review of a Double-Edged Sword.Journal of clinical medicine · 2025Review
- The association of the non-HDL-cholesterol to HDL-cholesterol ratio (NHHR) with obstructive sleep apnea among adults aged ≥ 40 years: results from NHANES 2015-2018.BMC public health · 2025Article
- Association of serum uric acid-to-high-density lipoprotein cholesterol ratio with obstructive sleep apnea: a cross-sectional study.Lipids in health and disease · 2025Article
- Characteristics and clinical value of intestinal metabolites in 4 to 6-year-old children with OSAHS.BMC pediatrics · 2025Article
- Cross-sectional study of the association between triglyceride glucose-body mass index and obstructive sleep apnea risk.World journal of diabetes · 2025Article
- Determinative sleep traits associated with dyslipidemia in obstructive sleep apnea patients.BMC pulmonary medicine · 2025Article
- The long-term impact of hypertriglyceridemia-waist phenotype on major adverse cardiovascular events in elderly patients with OSA.Sleep & breathing = Schlaf & Atmung · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Obstructive sleep apnoea (OSA) is associated with cardiovascular and metabolic comorbidities, including hypertension, dyslipidaemia, insulin resistance and atherosclerosis. Strong evidence suggests that OSA is associated with an altered lipid profile including elevated levels of triglyceride-rich lipoproteins and decreased levels of high-density lipoprotein (HDL). Intermittent hypoxia; sleep fragmentation; and consequential surges in the sympathetic activity, enhanced oxidative stress and systemic inflammation are the postulated mechanisms leading to metabolic alterations in OSA. Although the exact mechanisms of OSA-associated dyslipidaemia have not been fully elucidated, three main points have been found to be impaired: activated lipolysis in the adipose tissue, decreased lipid clearance from the circulation and accelerated de novo lipid synthesis. This is further complicated by the oxidisation of atherogenic lipoproteins, adipose tissue dysfunction, hormonal changes, and the reduced function of HDL particles in OSA. In this comprehensive review, we summarise and critically evaluate the current evidence about the possible mechanisms involved in OSA-associated dyslipidaemia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.