Evidence map›Paper›PMID 36359034›Full record

ArticleAnimals : an open access journal from MDPI2022

Effect of Selenium Nanoparticles and Mannan Oligosaccharide Supplementation on Growth Performance, Stress Indicators, and Intestinal Microarchitecture of Broilers Reared under High Stocking Density.

Hafiz Faseeh Ur Rehman, Hafsa Zaneb, Saima Masood, Muhammad Shahbaz Yousaf, Khizar Hayat, Khalid Abdul Majeed, Muhammad Zeeshan, Saima Ashraf, Imad Khan, Adnan Khan and 1 more

Open access · goldAbstract read
In one paragraph

Article in Animals : an open access journal from MDPI, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
3.3field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 25 citations in OpenAlex.

  1. Review
  2. Prebiotics and probiotics in animal nutrition: implications for food safety, sustainability, and circular production systems.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2026
    Review
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  11. Article
  12. Effect of dietaryJournal of advanced veterinary and animal research · 2024
    Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Hafiz Faseeh Ur RehmanDepartment of Anatomy and Histology, University of Veterinary and Animal Sciences, Lahore 54000, Pakistan.
Hafsa ZanebDepartment of Anatomy and Histology, University of Veterinary and Animal Sciences, Lahore 54000, Pakistan.
Saima MasoodDepartment of Anatomy and Histology, University of Veterinary and Animal Sciences, Lahore 54000, Pakistan.
Muhammad Shahbaz YousafDepartment of Physiology, University of Veterinary and Animal Sciences, Lahore 54000, Pakistan.
Khizar HayatDepartment of Anatomy and Histology, University of Veterinary and Animal Sciences, Lahore 54000, Pakistan.ORCID 0000-0002-0950-9351
Khalid Abdul MajeedDepartment of Physiology, University of Veterinary and Animal Sciences, Lahore 54000, Pakistan.ORCID 0000-0002-4929-4033
Muhammad ZeeshanDepartment of Anatomy and Histology, University of Veterinary and Animal Sciences, Lahore 54000, Pakistan.ORCID 0000-0001-6593-5083
Saima AshrafDepartment of Anatomy and Histology, University of Veterinary and Animal Sciences, Lahore 54000, Pakistan.
Imad KhanCollege of Veterinary Sciences and Animal Husbandry, Abdul Wali Khan University, Mardan 23200, Pakistan.
Adnan KhanInstitute of Chemical Sciences, University of Peshawar, Peshawar 25000, Pakistan.
Habib RehmanDepartment of Physiology, University of Veterinary and Animal Sciences, Lahore 54000, Pakistan.ORCID 0000-0002-8485-7962
University of Veterinary and Animal Sciences · PKAbdul Wali Khan University Mardan · PKUniversity of Peshawar · PK

Funding

Higher Education Commission 20-6966/R&D/NRPU
6 · The paper itself

Abstract

The current study investigated the potential of selenium nanoparticles (SeNPs) and mannan-oligosaccharide (MOS) supplementation in ameliorating high stocking density (HSD) stress in broilers. A total of 392 day-old male chicks were divided into seven groups with eight replicates (n = 7): NSD [basal diet (BD) + normal stocking density: 10 bird/m2], HSD [BD + high stocking density: 16 bird/m2], Se−HSD [BD + Selenium (Se) 0.15 mg/kg], MOS−HSD (BD + MOS 5 gm/kg), Se−MOS−HSD (BD + Se 0.15 mg/kg and MOS 5 gm/kg), SeNPs−HSD (BD + SeNPs 0.15 mg/kg) and SeNPs−MOS−HSD (BD + SeNPs 0.15 mg/kg and MOS-5 gm/kg). HSD stress decreased (p < 0.05) weekly body weight and body weight gain and increased (p < 0.05) FCR compared to the NSD group. Supplementation with SeNPs and the SeNPs−MOS combination improved (p < 0.05) the weekly body weight and FCR in HSD-stressed broilers during the 5th and 6th weeks. On day 21, HSD stress decreased (p < 0.05) duodenal villus height (VH) and villus surface area (VSA) and increased (p < 0.05) serum corticosterone and cholesterol compared to the NSD group. Supplementation with the SeNPs−MOS combination increased (p < 0.05) duodenal VH and VH:CD, and jejunal total goblet cell (TGC) density and decreased (p < 0.05) serum corticosterone and cholesterol and ileal intra-epithelial lymphocyte (IEL) density in HSD-stressed broilers. On day 42, HSD stress decreased (p < 0.05) duodenal and jejunal VH, VSA, VH:CD, PCNA positive cell density and TGC density, Ileal VSA and TGC density, and increased (p < 0.05) serum cholesterol and ileal IEL density compared to the NSD group. Supplementation with the SeNPs−MOS combination increased (p < 0.05) spleen and bursa absolute weights, duodenal VH, VSA, VH:CD, PCNA positive cell density and jejunal VH, VH:CD, and decreased (p < 0.05) serum cholesterol and ileal IEL density in HSD-stressed broilers. Our findings signify that HSD is stressful for broilers particularly during the finishing phase. Supplementation with the SeNPs−MOS combination mitigated HSD stress by partially improving the gut microarchitecture, gut barrier function and performance indicators.

Indexed as

body weightcorticosteronecrowding stressgoblet cellsgut healthhistomorphometryprebiotic

Identifiers

PMID36359034
PMCPMC9654113
OpenAlexW4307266455

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.