Evidence map›Paper›PMID 36358852›Full record

ArticleCancers2022

CDCA8/SNAI2 Complex Activates CD44 to Promote Proliferation and Invasion of Pancreatic Ductal Adenocarcinoma.

Jichun Gu, Yujie Guo, Jiali Du, Lei Kong, Junyuan Deng, Baian Tao, Hengchao Li, Chen Jin, Deliang Fu, Ji Li

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.0field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. RSC advances · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Jichun GuDepartment of Pancreatic Surgery, Huashan Hospital, Fudan University, Shanghai 200040, China.
Yujie GuoDepartment of Pancreatic Surgery, Huashan Hospital, Fudan University, Shanghai 200040, China.ORCID 0000-0002-2379-0725
Jiali DuDepartment of Pancreatic Surgery, Huashan Hospital, Fudan University, Shanghai 200040, China.
Lei KongDepartment of Pancreatic Surgery, Huashan Hospital, Fudan University, Shanghai 200040, China.
Junyuan DengDepartment of Pancreatic Surgery, Huashan Hospital, Fudan University, Shanghai 200040, China.
Baian TaoDepartment of Pancreatic Surgery, Huashan Hospital, Fudan University, Shanghai 200040, China.
Hengchao LiDepartment of Pancreatic Surgery, Huashan Hospital, Fudan University, Shanghai 200040, China.
Chen JinDepartment of Pancreatic Surgery, Huashan Hospital, Fudan University, Shanghai 200040, China.
Deliang FuDepartment of Pancreatic Surgery, Huashan Hospital, Fudan University, Shanghai 200040, China.
Ji LiDepartment of Pancreatic Surgery, Huashan Hospital, Fudan University, Shanghai 200040, China.ORCID 0000-0002-9842-4885
Fudan University · CN

Funding

National Natural Science Foundation of China 81772566
6 · The paper itself

Abstract

(1) Background: Recently, cell division cycle associated 8 (CDCA8) was found to be overexpressed in pancreatic ductal adenocarcinoma (PDAC). Here, we aimed to explore the specific mechanism of action of CDCA8 in PDAC progression. (2) Methods: All human PDAC samples and clinical data were collected from Huashan Hospital, Fudan University. All experimental studies were carried out using many in vitro and in vivo assays, including lentiviral transfection, real-time quantitative polymerase chain reaction (qPCR), western blotting, co-immunoprecipitation (Co-IP), chromatin IP (ChIP)-qPCR, dual-luciferase reporter, and in vivo imaging assays. (3) Results: Clinical data analysis of human PDAC samples revealed that CDCA8 overexpression were positively and negatively associated with tumor grade (

Indexed as

CD44CDCA8invasionPDACproliferationSNAI2

Identifiers

PMID36358852
PMCPMC9657053
OpenAlexW4308207088

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.