Evidence map›Paper›PMID 36358839›Full record

ArticleCancers2022

Glucose Enhances Pro-Tumorigenic Functions of Mammary Adipose-Derived Mesenchymal Stromal/Stem Cells on Breast Cancer Cell Lines.

Maria Rosaria Ambrosio, Giusy Mosca, Teresa Migliaccio, Domenico Liguoro, Gisella Nele, Fabrizio Schonauer, Francesco D'Andrea, Federica Liotti, Nella Prevete, Rosa Marina Melillo and 6 more

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
2.8field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.

  1. Advancements in Zebrafish Models for Breast Cancer Research: Unveiling Biomarkers, Targeted Therapies, and Personalized Medicine.Medical science monitor : international medical journal of experimental and clinical research · 2023
    Pooled it
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  3. Experiences and perceptions of cancer patients receiving virtual reality therapy: a meta‑synthesis of qualitative research.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 5 institutions in 1 country.

Maria Rosaria AmbrosioURT "Genomic of Diabetes", Institute for Experimental Endocrinology and Oncology "G. Salvatore", National Research Council (IEOS-CNR), Via Pansini 5, 80131 Naples, Italy.
Giusy MoscaDepartment of Translational Medicine, University of Naples "Federico II", Via Pansini 5, 80131 Naples, Italy.
Teresa MigliaccioDepartment of Translational Medicine, University of Naples "Federico II", Via Pansini 5, 80131 Naples, Italy.
Domenico LiguoroURT "Genomic of Diabetes", Institute for Experimental Endocrinology and Oncology "G. Salvatore", National Research Council (IEOS-CNR), Via Pansini 5, 80131 Naples, Italy.
Gisella NeleDepartment of Public Health, University of Naples "Federico II", Via Pansini 5, 80131 Naples, Italy.
Fabrizio SchonauerDepartment of Public Health, University of Naples "Federico II", Via Pansini 5, 80131 Naples, Italy.
Francesco D'AndreaDepartment of Public Health, University of Naples "Federico II", Via Pansini 5, 80131 Naples, Italy.
Federica LiottiDepartment of Molecular Medicine and Medical Biotechnology, University of Naples "Federico II", Via Pansini 5, 80131 Naples, Italy.ORCID 0000-0002-0145-988X
Nella PreveteURT "Genomic of Diabetes", Institute for Experimental Endocrinology and Oncology "G. Salvatore", National Research Council (IEOS-CNR), Via Pansini 5, 80131 Naples, Italy.ORCID 0000-0002-0186-5431
Rosa Marina MelilloURT "Genomic of Diabetes", Institute for Experimental Endocrinology and Oncology "G. Salvatore", National Research Council (IEOS-CNR), Via Pansini 5, 80131 Naples, Italy.ORCID 0000-0002-9233-5275
Carla RealeInstitute of Genetic Research "G. Salvatore" Biogem, Via Camporeale, 83031 Ariano Irpino, Italy.ORCID 0000-0001-7682-4784
Concetta AmbrosinoURT "Genomic of Diabetes", Institute for Experimental Endocrinology and Oncology "G. Salvatore", National Research Council (IEOS-CNR), Via Pansini 5, 80131 Naples, Italy.ORCID 0000-0003-3954-8842
Claudia MieleURT "Genomic of Diabetes", Institute for Experimental Endocrinology and Oncology "G. Salvatore", National Research Council (IEOS-CNR), Via Pansini 5, 80131 Naples, Italy.
Francesco BeguinotURT "Genomic of Diabetes", Institute for Experimental Endocrinology and Oncology "G. Salvatore", National Research Council (IEOS-CNR), Via Pansini 5, 80131 Naples, Italy.
Vittoria D'EspositoURT "Genomic of Diabetes", Institute for Experimental Endocrinology and Oncology "G. Salvatore", National Research Council (IEOS-CNR), Via Pansini 5, 80131 Naples, Italy.ORCID 0000-0002-3675-8062
Pietro FormisanoURT "Genomic of Diabetes", Institute for Experimental Endocrinology and Oncology "G. Salvatore", National Research Council (IEOS-CNR), Via Pansini 5, 80131 Naples, Italy.ORCID 0000-0001-7020-6870
Institute for Experimental Endocrinology and Oncology · ITFederico II University Hospital · ITUniversity of Naples Federico II · ITBiogem · ITUniversity of Sannio · IT

Funding

Italian Association for Cancer Research IG19001Regione Campania POR FESR 2014-2020 (RARE PLATNET, SATIN, COEPICA)
6 · The paper itself

Abstract

Adiposity and diabetes affect breast cancer (BC) progression. We addressed whether glucose may affect the interaction between mammary adipose tissue-derived mesenchymal stromal/stem cells (MAT-MSCs) and BC cells. Two-dimensional co-cultures and spheroids were established in 25 mM or 5.5 mM glucose (High Glucose-HG or Low Glucose-LG) by using MAT-MSCs and MCF7 or MDA-MB231 BC cells. Gene expression was measured by qPCR, while protein levels were measured by cytofluorimetry and ELISA. CD44

Indexed as

breast cancerglucosemammary adipose tissuemesenchymal stromal/stem cells

Identifiers

PMID36358839
PMCPMC9655059
OpenAlexW4308334119

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.