Evidence map›Paper›PMID 36358731›Full record

ArticleCancers2022

Real-World Use and Effectiveness of Carfilzomib Plus Dexamethasone in Relapsed/Refractory Multiple Myeloma in Europe.

Evangelos Terpos, Renato Zambello, Xavier Leleu, Thomas Kuehr, Sorina N Badelita, Eirini Katodritou, Alessandra Brescianini, Tony Liang, Sally Wetten, Jo Caers

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Cancers, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03091127 (Real-world Use of Carfilzomib Among Multiple Myeloma Patients in Europe Who Have Received at Least One Prior Therapy.), which is not on this map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.6field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03091127 completednot on this map

Real-world Use of Carfilzomib Among Multiple Myeloma Patients in Europe Who Have Received at Least One Prior Therapy.

TypeobservationalSponsorAmgenRan2017 to 2020Enrolled705ConditionsMultiple Myeloma
3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 9 institutions in 8 countries.

Evangelos TerposDepartment of Clinical Therapeutics, School of Medicine, National and Kapodistrian University of Athens, 11528 Athens, Greece.ORCID 0000-0001-5133-1422
Renato ZambelloHematology and Clinical Immunology Branch, Department of Medicine, University of Padua, 35128 Padua, Italy.ORCID 0000-0002-8799-5324
Xavier LeleuDepartment of Hematology, University Hospital Center La Miletrie and Inserm, CIC 1402, 86000 Poitiers, France.
Thomas KuehrDepartment of Internal Medicine IV, Academic Teaching Hospital Wels-Grieskirchen, 4600 Wels, Austria.
Sorina N BadelitaFundeni Clinical Institute, 72437 Bucharest, Romania.
Eirini KatodritouDepartment of Hematology, Theagenio Cancer Hospital, 54007 Thessaloniki, Greece.ORCID 0000-0001-9404-807X
Alessandra BrescianiniAmgen (Europe) GmbH, 6343 Rotkreuz, Switzerland.
Tony LiangParexel International, Taipei 11071, Taiwan.
Sally WettenAmgen Ltd., Uxbridge UB8 1DH, UK.
Jo CaersDepartment of Hematology, Liege University Hospital Center, 4000 Liege, Belgium.
Amgen (Switzerland) · CHAmgen (United Kingdom) · GBInserm · FRInstitutul Clinic Fundeni · ROKlinikum Wels-Grieskirchen · ATNational and Kapodistrian University of Athens · GRTheageneio General Hospital · GRUniversity of Liège · BEUniversity of Padua · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This prospective, observational study examined the real-world use of carfilzomib across 11 European countries in adults with relapsed/refractory multiple myeloma (RRMM) who received at least one prior line of therapy. Carfilzomib and dexamethasone (Kd) use, effectiveness and safety were analyzed. In total, 271 patients received Kd among 701 adults enrolled. The median relative dose intensity of carfilzomib was 82.7% (20/56 mg/m

Indexed as

carfilzomibmultiple myelomaproteasome inhibitorreal worldrelapsed/refractory

Identifiers

PMID36358731
PMCPMC9657308
OpenAlexW4307941514

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.