Evidence map›Paper›PMID 36358622›Full record

ArticleCancers2022

Evaluation of Concomitant Use of Anticancer Drugs and Herbal Products: From Interactions to Synergic Activity.

Massimiliano Berretta, Lissandra Dal Lago, Mattia Tinazzi, Andrea Ronchi, Gaspare La Rocca, Liliana Montella, Raffaele Di Francia, Bianca Arianna Facchini, Alessia Bignucolo, Monica Montopoli

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
4.9field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Anti-inflammatory & anti-allergy agents in medicinal chemistry · 2025
    Article
  7. Review
  8. Review
  9. Anti-Cancer Potential of Edible/Medicinal Mushrooms in Breast Cancer.International journal of molecular sciences · 2023
    Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 8 institutions in 3 countries.

Massimiliano BerrettaDepartment of Clinical and Experimental Medicine, University of Messina, 98122 Messina, Italy.
Lissandra Dal LagoDepartment of Medicine, Institut Jules Bordet, Université Libre de Bruxelles (ULB), 1070 Brussels, Belgium.
Mattia TinazziDepartment of Pharmaceutical and Pharmacological Sciences, University of Padova, 35123 Padova, Italy.
Andrea RonchiPathology Unit, Department of Mental Health, Physic and Preventive Medicine University of Campania "Luigi Vanvitelli", 80131 Naples, Italy.
Gaspare La RoccaCancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.ORCID 0000-0003-1277-0566
Liliana MontellaDivision of Medical Oncology, "Santa Maria delle Grazie" Hospital, ASL Napoli 2 NORD-, 80078 Pozzuoli, Italy.ORCID 0000-0002-6397-086X
Raffaele Di FranciaGruppo Oncologico Ricercatori Italiani (GORI-ONLUS), 33170 Pordenone, Italy.
Bianca Arianna FacchiniDepartment of Precision Medicine, University of Study of Campania "L. Vanvitelli", 80131 Naples, Italy.
Alessia BignucoloIntegrative Medicine Research Group (IMRG), Noceto, 43015 Parma, Italy.ORCID 0000-0003-4379-291X
Monica MontopoliIntegrative Medicine Research Group (IMRG), Noceto, 43015 Parma, Italy.ORCID 0000-0001-6182-4132
University of Campania "Luigi Vanvitelli" · ITUniversity of Padua · ITCentro di Riferimento Oncologico · ITItalian Oncology Group of Clinical Research · ITMemorial Sloan Kettering Cancer Center · USOspedale Santa Maria · ITUniversité Libre de Bruxelles · BEUniversity of Messina · IT

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI SELWYN M VICKERS · 1985 to 2026
$347.4M
NCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

CAM is used by about 40% of cancer patients in Western Countries, with peaks of 80% for breast cancer patients. Cancer patients use CAM to boost immune function, to control cancer symptoms and treatment-related side effects, and to improve health-related quality of life (HR-QoL) and survival. Unfortunately, self-prescription of natural remedies in cancer patients can lead to unexpected toxicities and can reduce the effectiveness of cancer therapy. Although CAM usually refers to all the "natural or organic" products/methods that are generally considered less toxic, there are concerns about drug interactions, especially in patients participating in clinical trials with experimental agents. Despite the claims of the promising and potential benefits made by prescribers, many CAMs lack clear scientific evidence of their safety and efficacy. Given the widespread use of CAM-both clearly declared and overt-in this review, we focused on the most important known data on the risk of interactions between biologics and oncology drugs with the goal of opening up CAM in accordance with the meaning of integrative medicine.

Indexed as

alternativecancerchemotherapycomplementaryinteractionsmedicinesynergism

Identifiers

PMID36358622
PMCPMC9657145
OpenAlexW4307373108

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.