Evidence map›Paper›PMID 36358463›Full record

ArticleAntioxidants (Basel, Switzerland)2022

Do Intestinal Unicellular Parasites Have a Role in the Inflammatory and Redox Status among the Severely Obese?

Jana Caudet, María Trelis, Susana Cifre, Gabriela Tapia, José M Soriano, Regina Rodrigo, Juan F Merino-Torres

Registry-linked trialAbstract read
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06481020 (Effect of Plant Sterols on Inflammatory, Endothelial Function and Oxidative Stress Markers, Microbiota and Sterol Metabolism in a Cardiovascular Risk Population), which is not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06481020 naunknown statusnot on this mapstarted 2024, after this paper: background citation

Effect of Plant Sterols on Inflammatory, Endothelial Function and Oxidative Stress Markers, Microbiota and Sterol Metabolism in a Cardiovascular Risk Population

TypeinterventionalSponsorUniversity of ValenciaRan2024 to 2025Enrolled42ConditionsCardiovascular Diseases, Hypercholesterolemia, Prediabetic State, Overweight and ObesityArmsPlant sterols 2g/day, Placebo
3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jana CaudetDepartment of Endocrinology and Nutrition, University and Polytechnic Hospital La Fe, 46026 Valencia, Spain.ORCID 0000-0002-0124-1100
María TrelisJoint Research Unit on Endocrinology, Nutrition and Clinical Dietetics, Health Research Institute Hospital La Fe-University of Valencia, 46026 Valencia, Spain.ORCID 0000-0002-5977-3337
Susana CifreJoint Research Unit on Endocrinology, Nutrition and Clinical Dietetics, Health Research Institute Hospital La Fe-University of Valencia, 46026 Valencia, Spain.ORCID 0000-0003-1975-5828
Gabriela TapiaParasite & Health Research Group, Area of Parasitology, Department of Pharmacy and Pharmaceutical Technology and Parasitology, University of Valencia, 46010 Valencia, Spain.
José M SorianoJoint Research Unit on Endocrinology, Nutrition and Clinical Dietetics, Health Research Institute Hospital La Fe-University of Valencia, 46026 Valencia, Spain.ORCID 0000-0003-2846-1311
Regina RodrigoJoint Research Unit on Endocrinology, Nutrition and Clinical Dietetics, Health Research Institute Hospital La Fe-University of Valencia, 46026 Valencia, Spain.ORCID 0000-0001-5875-986X
Juan F Merino-TorresDepartment of Endocrinology and Nutrition, University and Polytechnic Hospital La Fe, 46026 Valencia, Spain.ORCID 0000-0002-0191-4504

Funding

La Fe Health Research Institute Research grants: 2014/0396 and 2015/0359
6 · The paper itself

Abstract

The diagnosis of obesity comprises subjects with totally different phenotypes and metabolic profiles. Systemic inflammation and oxidative stress derived from the white adipose tissue are suggested as the link between this disease and the development of insulin resistance and metabolic comorbidities. The presence of unicellular eukaryotic parasites colonizing the human gut ecosystem is a common circumstance, and yet their influence on the inflammatory and redox status of the obese host has not been assessed. Herein, a set of inflammatory and redox biomarkers were assessed together with a parasitological analysis of 97 severely obese subjects. Information was also collected on insulin resistance and on the antioxidant composition of the diet. The global prevalence of intestinal unicellular parasites was 49.5%, with

Indexed as

antioxidant defenseBlastocystisDientamoeba fragilisfood antioxidantsGiardia intestinalislipoinflammationobesityoxidative stress

Identifiers

PMID36358463
PMCPMC9686585

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.