Evidence map›Paper›PMID 36358458›Full record

ArticleAntioxidants (Basel, Switzerland)2022

Apple Polyphenol Diet Extends Lifespan, Slows down Mitotic Rate and Reduces Morphometric Parameters in Drosophila Melanogaster: A Comparison between Three Different Apple Cultivars.

Silvia Bongiorni, Ivan Arisi, Brunella Ceccantoni, Cristina Rossi, Camilla Cresta, Simona Castellani, Ivano Forgione, Sara Rinalducci, Rosario Muleo, Giorgio Prantera

Abstract read
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Antioxidant Activity ofAntioxidants (Basel, Switzerland) · 2025
    Article
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  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Silvia BongiorniDepartment of Ecological and Biological Sciences (DEB), University of Tuscia, 01100 Viterbo, Italy.
Ivan ArisiBioinformatics Facility European Brain Research Institute (EBRI) "Rita Levi-Montalcini", and Institute of Translational Pharmacology National Research Council (CNR), Viale Regina Elena 295, 00161 Roma, Italy.
Brunella CeccantoniDepartment for Innovation in Biological, Agro-Food and Forest Systems (DIBAF), University of Tuscia, 01100 Viterbo, Italy.
Cristina RossiDepartment of Ecological and Biological Sciences (DEB), University of Tuscia, 01100 Viterbo, Italy.
Camilla CrestaDepartment of Ecological and Biological Sciences (DEB), University of Tuscia, 01100 Viterbo, Italy.ORCID 0000-0002-9844-4763
Simona CastellaniTree Physiology and Fruit Crop Biotechnology Laboratory, Department of Agriculture and Forest Sciences (DAFNE), University of Tuscia, 01100 Viterbo, Italy.ORCID 0000-0001-7091-7680
Ivano ForgioneTree Physiology and Fruit Crop Biotechnology Laboratory, Department of Agriculture and Forest Sciences (DAFNE), University of Tuscia, 01100 Viterbo, Italy.ORCID 0000-0002-9512-3964
Sara RinalducciDepartment of Ecological and Biological Sciences (DEB), University of Tuscia, 01100 Viterbo, Italy.
Rosario MuleoTree Physiology and Fruit Crop Biotechnology Laboratory, Department of Agriculture and Forest Sciences (DAFNE), University of Tuscia, 01100 Viterbo, Italy.ORCID 0000-0001-5372-0675
Giorgio PranteraDepartment of Ecological and Biological Sciences (DEB), University of Tuscia, 01100 Viterbo, Italy.ORCID 0000-0003-0970-9561

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Plant-derived polyphenols exhibit beneficial effects on physiological and pathological processes, including cancer and neurodegenerative disorders, mainly because of their antioxidant activity. Apples are highly enriched in these compounds, mainly in their peel. The Tuscia Red (TR) apple variety exhibits the peculiar characteristic of depositing high quantities of polyphenols in the pulp, the edible part of the fruit. Since polyphenols, as any natural product, cannot be considered a panacea per se, in this paper, we propose to assess the biological effects of TR flesh extracts, in comparison with two commercial varieties, in a model system, the insect

Indexed as

apple polyphenolsclimbing assayDrosophila melanogasterlifespanmitotic indexmodel organismsred flesh apple

Identifiers

PMID36358458
PMCPMC9686679

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.