Evidence map›Paper›PMID 36358408›Full record

ArticleBrain sciences2022

Endoscopic Treatment of Rathke's Cleft Cysts: The Case for Simple Fenestration.

Matthias Millesi, Carolyn Lai, Ruth Lau, Vincent Chen Ye, Kaiyun Yang, Matheus Leite, Nilesh Mohan, Ozgur Mete, Shereen Ezzat, Fred Gentili and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 2 pooled it
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 2 syntheses or guidelines pooled it, 5 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 2 countries.

Matthias MillesiDivision of Neurosurgery, Toronto Western Hospital/University Health Network, University of Toronto, Toronto, ON M5T 2S8, Canada.ORCID 0000-0001-9503-4278
Carolyn LaiDivision of Neurosurgery, Toronto Western Hospital/University Health Network, University of Toronto, Toronto, ON M5T 2S8, Canada.
Ruth LauDivision of Neurosurgery, Toronto Western Hospital/University Health Network, University of Toronto, Toronto, ON M5T 2S8, Canada.
Vincent Chen YeDivision of Neurosurgery, Toronto Western Hospital/University Health Network, University of Toronto, Toronto, ON M5T 2S8, Canada.
Kaiyun YangDivision of Neurosurgery, Toronto Western Hospital/University Health Network, University of Toronto, Toronto, ON M5T 2S8, Canada.
Matheus LeiteDivision of Neurosurgery, Toronto Western Hospital/University Health Network, University of Toronto, Toronto, ON M5T 2S8, Canada.
Nilesh MohanDivision of Neurosurgery, Toronto Western Hospital/University Health Network, University of Toronto, Toronto, ON M5T 2S8, Canada.ORCID 0000-0001-8589-5867
Ozgur MeteDepartment of Pathology, University Health Network, University of Toronto, Toronto, ON M5G 2C4, Canada.
Shereen EzzatDepartment of Endocrine Oncology, Princess Margaret Cancer Centre, University of Toronto, Toronto, ON M5G 1X5, Canada.
Fred GentiliDivision of Neurosurgery, Toronto Western Hospital/University Health Network, University of Toronto, Toronto, ON M5T 2S8, Canada.
Gelareh ZadehDivision of Neurosurgery, Toronto Western Hospital/University Health Network, University of Toronto, Toronto, ON M5T 2S8, Canada.
Aristotelis KalyvasDivision of Neurosurgery, Toronto Western Hospital/University Health Network, University of Toronto, Toronto, ON M5T 2S8, Canada.
University Health Network · CAUniversity of Toronto · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundRathke's cleft cysts (RCC) arise from the pars intermedia because of incomplete regression of the embryologic Rathke pouch. A subset of RCC becomes symptomatic causing headaches, visual and endocrinological disturbances such that surgical intervention is indicated. Several points in surgical management remain controversial including operative strategy (simple fenestration (SF) vs complete cyst wall resection (CWR)) as well as reconstructive techniques.

methodsA retrospective analysis was conducted of pathologically confirmed RCC operated on by endoscopic endonasal approach from 2006 to 2019. Pre-operative symptoms, imaging characteristics, operative strategy, symptom response, complications and recurrences were recorded.

resultsThirty-nine patients were identified. Thirty-three underwent SF and six underwent CWR. Worsening pituitary function was significantly increased with CWR (50%) compared to SF (3%) (

conclusionsThe current series illustrates variability in the surgical management of RCCs. SF with closed reconstruction is a reasonable operative strategy for most symptomatic RCCs cases while CWR can be reserved for selected cases.

Indexed as

endoscopyRathke’s cleft cystsimple fenestration

Identifiers

PMID36358408
PMCPMC9688520
OpenAlexW4307988958

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.