Evidence map›Paper›PMID 36358391›Full record

ArticleBrain sciences2022

Irreversible Electroporation Mediates Glioma Apoptosis via Upregulation of

Shuangquan Yu, Lingchao Chen, Kun Song, Ting Shu, Zheng Fang, Lujia Ding, Jilong Liu, Lei Jiang, Guanqing Zhang, Bing Zhang and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Heat Acclimation Enhances Brain Resilience to Acute Thermal Stress inAnimals : an open access journal from MDPI · 2025
    Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Shuangquan YuDepartment of Neurosurgery, Huashan Hospital Shanghai Medical College, Fudan University, Shanghai 200040, China.ORCID 0000-0002-0671-0578
Lingchao ChenDepartment of Neurosurgery, Huashan Hospital Shanghai Medical College, Fudan University, Shanghai 200040, China.
Kun SongDepartment of Neurosurgery, Huashan Hospital Shanghai Medical College, Fudan University, Shanghai 200040, China.
Ting ShuIntelligent Energy-Based Tumor Ablation Laboratory, School of Mechatronic Engineering and Automation, Shanghai University, Shanghai 200444, China.
Zheng FangDivision of Biomedical Engineering, University of Saskatchewan, Saskatoon, SK S7N 5A9, Canada.ORCID 0000-0001-5479-7578
Lujia DingDivision of Biomedical Engineering, University of Saskatchewan, Saskatoon, SK S7N 5A9, Canada.
Jilong LiuIntelligent Energy-Based Tumor Ablation Laboratory, School of Mechatronic Engineering and Automation, Shanghai University, Shanghai 200444, China.
Lei JiangIntelligent Energy-Based Tumor Ablation Laboratory, School of Mechatronic Engineering and Automation, Shanghai University, Shanghai 200444, China.
Guanqing ZhangBiomedical Science and Technology Research Center, School of Mechatronic Engineering and Automation, Shanghai University, Shanghai 200444, China.
Bing ZhangIntelligent Energy-Based Tumor Ablation Laboratory, School of Mechatronic Engineering and Automation, Shanghai University, Shanghai 200444, China.ORCID 0000-0001-5650-2518
Zhiyong QinDepartment of Neurosurgery, Huashan Hospital Shanghai Medical College, Fudan University, Shanghai 200040, China.
Shanghai University · CNFudan University · CNUniversity of Saskatchewan · CA

Funding

the National Natural Science Foundation of China 81801795
6 · The paper itself

Abstract

The heat-sink effect and thermal damage of conventional thermal ablative technologies can be minimized by irreversible electroporation (IRE), which results in clear ablative boundaries and conservation of blood vessels, facilitating maximal safe surgical resection for glioblastoma. Although much comparative data about the death forms in IRE have been published, the comprehensive genetic regulatory mechanism for apoptosis, among other forms of regulatory cell death (RCD), remains elusive. We investigated the electric field intensity threshold for apoptosis/necrosis (YO-PRO-1/PI co-staining) of the U251 human malignant glioma cell line with stepwise increased uniform field intensity. Time course samples (0-6 h) of apoptosis induction and sham treatment were collected for transcriptome sequencing. Sequencing showed that transcription factor

Indexed as

AP-1apoptosisBimFOSgliomairreversible electroporationJUNregulatory cell death

Identifiers

PMID36358391
PMCPMC9688309
OpenAlexW4307944106

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.