Evidence map›Paper›PMID 36358383›Full record

ArticleBrain sciences2022

Selective Neural Electrical Stimulation of an Injured Facial Nerve Using Chronically Implanted Dual Cuff Electrodes.

Arash Abiri, Steven Chau, Nathan R James, Khodayar Goshtasbi, Jack L Birkenbeuel, Ronald Sahyouni, Robert Edwards, Hamid R Djalilian, Harrison W Lin

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Arash AbiriDepartment of Otolaryngology-Head and Neck Surgery, University of California, Irvine Medical Center, Orange, CA 92868, USA.ORCID 0000-0003-2656-1060
Steven ChauDepartment of Otolaryngology-Head and Neck Surgery, University of California, Irvine Medical Center, Orange, CA 92868, USA.
Nathan R JamesDepartment of Otolaryngology-Head and Neck Surgery, University of California, Irvine Medical Center, Orange, CA 92868, USA.
Khodayar GoshtasbiDepartment of Otolaryngology-Head and Neck Surgery, University of California, Irvine Medical Center, Orange, CA 92868, USA.
Jack L BirkenbeuelDepartment of Otolaryngology-Head and Neck Surgery, University of California, Irvine Medical Center, Orange, CA 92868, USA.
Ronald SahyouniDepartment of Otolaryngology-Head and Neck Surgery, University of California, Irvine Medical Center, Orange, CA 92868, USA.ORCID 0000-0002-2124-0535
Robert EdwardsDepartment of Pathology and Laboratory Medicine, University of California, Irvine School of Medicine, Irvine, CA 92617, USA.
Hamid R DjalilianDepartment of Otolaryngology-Head and Neck Surgery, University of California, Irvine Medical Center, Orange, CA 92868, USA.
Harrison W LinDepartment of Otolaryngology-Head and Neck Surgery, University of California, Irvine Medical Center, Orange, CA 92868, USA.
University of California, Irvine Medical Center · USUniversity of California, Irvine · US

Funding

University of California Health Participation in the National COVID Cohort Collaborative (N3C)UL1TR001414 · NCATS · UNIVERSITY OF CALIFORNIA-IRVINE · PI COOPER, DAN M, VILAIN, ERIC J. · 2015 to 2023
$35.1M
MEDICAL SCIENTIST TRAINING PROGRAMT32GM008620 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI GOLDIN, ALAN L · 1999 to 2023
$8.1M
Institutional Career Development CoreKL2TR001416 · NCATS · UNIVERSITY OF CALIFORNIA-IRVINE · PI CAIOZZO, VINCENT JAMES, DEMETRIOU, MICHAEL · 2015 to 2023
$5.6M
NCATS NIH HHS KL2 TR001416NCATS NIH HHS UL1 TR001414NIGMS NIH HHS T32GM008620
6 · The paper itself

Abstract

Facial nerve (FN) injury can lead to debilitating and permanent facial paresis/paralysis (FP), where facial muscles progressively lose tone, atrophy, and ultimately reduce to scar tissue. Despite considerable efforts in the recent decades, therapies for FP still possess high failure rates and provide inadequate recovery of muscle function. In this pilot study, we used a feline model to demonstrate the potential for chronically implanted multichannel dual-cuff electrodes (MCE) to selectively stimulate injured facial nerves at low current intensities to avoid stimulus-induced neural injury. Selective facial muscle activation was achieved over six months after FN injury and MCE implantation in two domestic shorthaired cats (

Indexed as

facial nervefacial paralysisflexible neural electrodesimplantable neural interfacesneuroprostheticsneurorehabilitation

Identifiers

PMID36358383
PMCPMC9688741
OpenAlexW4308277356

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.