Evidence map›Paper›PMID 36358216›Full record

ArticleAntibiotics (Basel, Switzerland)2022

Chimeric Peptides Derived from Bovine Lactoferricin and Buforin II: Antifungal Activity against Reference Strains and Clinical Isolates of

Katherine Aguirre-Guataqui, Mateo Márquez-Torres, Héctor Manuel Pineda-Castañeda, Yerly Vargas-Casanova, Andrés Ceballos-Garzon, Zuly Jenny Rivera-Monroy, Javier Eduardo García-Castañeda, Claudia Marcela Parra-Giraldo

Open access · goldAbstract read
In one paragraph

Article in Antibiotics (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.4field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Katherine Aguirre-GuataquiHuman Proteomics and Mycosis Unit, Infectious Diseases Research Group, Department of Microbiology, Carrera 7 # 43-82 Lab 404 Building 52, Pontificia Universidad Javeriana, Bogotá 111321, Colombia.ORCID 0000-0002-9122-678X
Mateo Márquez-TorresBacteriology Department, Universidad Colegio Mayor de Cundinamarca, Bogotá 111321, Colombia.
Héctor Manuel Pineda-CastañedaSynthesis and Application of Peptide Molecules Faculty of Sciences, Universidad Nacional of Colombia, Bogotá 111321, Colombia.ORCID 0000-0002-9081-0546
Yerly Vargas-CasanovaHuman Proteomics and Mycosis Unit, Infectious Diseases Research Group, Department of Microbiology, Carrera 7 # 43-82 Lab 404 Building 52, Pontificia Universidad Javeriana, Bogotá 111321, Colombia.ORCID 0000-0003-4788-8150
Andrés Ceballos-GarzonMEDiS, INRAE, Université Clermont Auvergne, 63000 Clermont-Ferrand, France.ORCID 0000-0002-0743-6857
Zuly Jenny Rivera-MonroySynthesis and Application of Peptide Molecules Faculty of Sciences, Universidad Nacional of Colombia, Bogotá 111321, Colombia.ORCID 0000-0001-6915-8488
Javier Eduardo García-CastañedaSynthesis and Application of Peptide Molecules Faculty of Sciences, Universidad Nacional of Colombia, Bogotá 111321, Colombia.ORCID 0000-0001-6882-4397
Claudia Marcela Parra-GiraldoHuman Proteomics and Mycosis Unit, Infectious Diseases Research Group, Department of Microbiology, Carrera 7 # 43-82 Lab 404 Building 52, Pontificia Universidad Javeriana, Bogotá 111321, Colombia.ORCID 0000-0003-1302-5429
Pontificia Universidad Javeriana · COUniversidad Nacional de Colombia · COUniversidad Colegio Mayor de Cundinamarca · COUniversité Clermont Auvergne · FR

Funding

Colciencias COLCIENCIAS 807-2018, Project: "Diseño de una formulación para el tratamiento de la candidiasis invasiva multidrogoresistente, basada en péptidos de LfcinB libres o nanoencapsulados. Code 120380763646, contract RC N° 715-2018.
6 · The paper itself

Abstract

Antimicrobial peptides (AMPs) are considered to be a valuable source for the identification and/or design of promising candidates for the development of antifungal treatments, since they have advantages such as lower tendency to induce resistance, ease of production, and high purity and safety. Bovine lactoferricin (LfcinB) and buforin II (BFII) are AMPs to which great antimicrobial potential has been attributed. The minimum motives with antimicrobial activity derived from LfcinB and BFII are RRWQWR and RLLR, respectively. Nine chimeras containing the minimum motives of both peptides were synthesized and their antifungal activity against fluconazole (FLC)-sensitive and resistant

Indexed as

antimicrobial peptidesbovine lactoferricinBuforin IICandida albicanschimeras

Identifiers

PMID36358216
PMCPMC9686985
OpenAlexW4308440128

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.