Evidence map›Paper›PMID 36358203›Full record

ArticleAntibiotics (Basel, Switzerland)2022

Synthesis and Antimicrobial Activity of Sulfenimines Based on Pinane Hydroxythiols.

Nikita O Ilchenko, Denis V Sudarikov, Roman V Rumyantcev, Diana R Baidamshina, Nargiza D Zakarova, Monyr Nait Yahia, Airat R Kayumov, Aleksandr V Kutchin, Svetlana A Rubtsova

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antibiotics (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Nikita O IlchenkoInstitute of Chemistry, Federal Research Centre "Komi Scientific Centre", Ural Branch of the Russian Academy of Sciences, Pervomayskaya St. 48, 167000 Syktyvkar, Komi Republic, Russia.
Denis V SudarikovInstitute of Chemistry, Federal Research Centre "Komi Scientific Centre", Ural Branch of the Russian Academy of Sciences, Pervomayskaya St. 48, 167000 Syktyvkar, Komi Republic, Russia.ORCID 0000-0001-5640-6956
Roman V RumyantcevG.A. Razuvaev Institute of Organometallic Chemistry of Russian Academy of Sciences, 49 Tropinina St., 603950 Nizhny Novgorod, Russia.ORCID 0000-0003-0198-3806
Diana R BaidamshinaInstitute of Fundamental Medicine and Biology, Kazan Federal University, 18 Kremlevskaya Street, 420008 Kazan, Russia.
Nargiza D ZakarovaInstitute of Fundamental Medicine and Biology, Kazan Federal University, 18 Kremlevskaya Street, 420008 Kazan, Russia.
Monyr Nait YahiaInstitute of Fundamental Medicine and Biology, Kazan Federal University, 18 Kremlevskaya Street, 420008 Kazan, Russia.
Airat R KayumovInstitute of Fundamental Medicine and Biology, Kazan Federal University, 18 Kremlevskaya Street, 420008 Kazan, Russia.ORCID 0000-0001-7195-1557
Aleksandr V KutchinInstitute of Chemistry, Federal Research Centre "Komi Scientific Centre", Ural Branch of the Russian Academy of Sciences, Pervomayskaya St. 48, 167000 Syktyvkar, Komi Republic, Russia.
Svetlana A RubtsovaInstitute of Chemistry, Federal Research Centre "Komi Scientific Centre", Ural Branch of the Russian Academy of Sciences, Pervomayskaya St. 48, 167000 Syktyvkar, Komi Republic, Russia.

Funding

Russian Science Foundation 21-13-00245
6 · The paper itself

Abstract

The widespread presence of multidrug-resistant pathogenic microorganisms challenges the development of novel chemotype antimicrobials, insensitive to microbial tools of resistance. To date, various monoterpenoids have been shown as potential antimicrobials. Among many classes of molecules with antimicrobial activity, terpenes and terpenoids are an attractive basis for the design of antimicrobials because of their low toxicity and availability for various modifications. In this work, we report on the synthesis of sulfenimines from chiral trifluoromethylated and non-fluorinated pinane-type thiols. Final compounds were obtained with yields of up to 81%. Among the 13 sulfenimines obtained, 3 compounds were able to repress the growth of both bacteria (

Indexed as

antibacterialantifungal activityCF3-containing hydroxythiolmonoterpenoidspinanesulfenimines

Identifiers

PMID36358203
PMCPMC9686613

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.