Evidence map›Paper›PMID 36358201›Full record

ArticleAntibiotics (Basel, Switzerland)2022

Effects of Vitamin D on the Renin-Angiotensin System and Acute Childhood Pneumonia.

Andrea Zovi, Francesco Ferrara, Roberta Pasquinucci, Livia Nava, Antonio Vitiello, Roberto Arrigoni, Andrea Ballini, Stefania Cantore, Raffele Palmirotta, Marina Di Domenico and 2 more

Open access · goldAbstract read
In one paragraph

Article in Antibiotics (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. Individual and Combined Cardioprotective Effects of 1,25(OH)Journal of biochemical and molecular toxicology · 2026
    Article
  3. Article
  4. Review
  5. Article
  6. Current Views About the Link between SARS-CoV-2 and the Liver: Friends or Foe?Endocrine, metabolic & immune disorders drug targets · 2024
    Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Andrea ZoviMinistry of Health, Viale Giorgio Ribotta 5, 00144 Rome, Italy.ORCID 0000-0002-6528-2171
Francesco FerraraPharmaceutical Department, Asl Napoli 3 Sud, Dell'amicizia Street 22, Nola, 80035 Naples, Italy.ORCID 0000-0001-9298-6783
Roberta PasquinucciPharmaceutical Department, Asl Napoli 3 Sud, Dell'amicizia Street 22, Nola, 80035 Naples, Italy.
Livia NavaPharmaceutical Department, Asl Napoli 2 Nord, Frattamaggiore, 80027 Naples, Italy.
Antonio VitielloMinistry of Health, Viale Giorgio Ribotta 5, 00144 Rome, Italy.
Roberto ArrigoniCNR Institute of Biomembranes, Bioenergetics and Molecular Biotechnologies (IBIOM), 70124 Bari, Italy.ORCID 0000-0001-5361-4346
Andrea BalliniDepartment of Precision Medicine, University of Campania "Luigi Vanvitelli", 80100 Naples, Italy.ORCID 0000-0001-8758-1415
Stefania CantoreIndependent Researcher, Regional Dental Community Service "Sorriso&Benessere-Ricerca e Clinica", 70129 Bari, Italy.ORCID 0000-0001-9521-2521
Raffele PalmirottaInterdisciplinary Department of Medicine, School of Medicine, University of Bari "Aldo Moro", 70129 Bari, Italy.ORCID 0000-0002-9401-7377
Marina Di DomenicoDepartment of Precision Medicine, University of Campania "Luigi Vanvitelli", 80100 Naples, Italy.
Luigi SantacroceInterdisciplinary Department of Medicine, School of Medicine, University of Bari "Aldo Moro", 70129 Bari, Italy.ORCID 0000-0001-5671-8124
Mariarosaria BoccellinoDepartment of Precision Medicine, University of Campania "Luigi Vanvitelli", 80100 Naples, Italy.ORCID 0000-0001-6989-010X
University of Campania "Luigi Vanvitelli" · ITMinistero della Salute · ITUniversity of Bari Aldo Moro · ITInstitute of Biomembranes, Bioenergetics and Molecular Biotechnologies · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Vitamin D promotes kidney calcium reabsorption and regulates calcium and phosphate metabolism, as well as the intestinal absorption of calcium and phosphorus and bone mineralization events. Vitamin D is also known for its immunomodulatory properties. It has been shown in the literature that the active form of vitamin D, 1,25-dihydroxyvitamin D, performs multiple functions in the adaptive and innate immune system, as well as acting on the endothelial membrane. Recent evidence shows that vitamin D is a negative endocrine modulator of the renin-angiotensin system (RAS), with protection from diseases leading to lung damage, such as pneumonia caused by various pathogens. Vitamin D support associated with the use of antibiotics could be crucial to counteract these infectious diseases.

Indexed as

antibioticsinfectious diseasepharmacologypneumoniarenin–angiotensin systemvitamin D

Identifiers

PMID36358201
PMCPMC9686887
OpenAlexW4308352363

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.