Observational studyObstetrics and gynecology2022
Allostatic Load and Adverse Pregnancy Outcomes.
Observational study in Obstetrics and gynecology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Prenatal allostatic load and adverse pregnancy outcomes: a systematic review and meta-analysis.PeerJ · 2026Pooled it
- Effects of Race, Ethnicity and Socioeconomic Deprivation on Postpartum Haemorrhage in High-Income Countries: A Systematic Review and Meta-Analysis.BJOG : an international journal of obstetrics and gynaecology · 2025Pooled it
- The cost of chronic strain: Sleep disruption, allostatic load, and the impact on adverse pregnancy outcomes.Pregnancy (Hoboken, N.J.) · 2026Article
- Comparing allostatic load scoring methods and timing: their links to preterm birth outcomes.AJOG global reports · 2026Article
- Allostatic Load, Neighborhood Disadvantage, and Birth Outcomes.Journal of racial and ethnic health disparities · 2026Article
- The association between social vulnerability and racial disparities in preterm birth.Pregnancy (Hoboken, N.J.) · 2026Article
- Stress Trajectory and Hypertension 2 to 7 Years After Delivery: A nuMoM2b-HHS Study.Hypertension (Dallas, Tex. : 1979) · 2026Article
- Minimum Wage Policies and Obstetric Disorders in the U.S.American journal of preventive medicine · 2026Article
- Longitudinal study on the relationship between DASH-style dietary pattern and allostatic load in Chinese pregnant women.Nutrition research and practice · 2026Article
- Allostatic Load Mediates Associations Between Race and Ethnicity and Hypertensive Disorders of Pregnancy.Obstetrics and gynecology · 2026Article
- Profile of severe maternal morbidity cases by nationality in Colombia: analysis of national surveillance data, 2021.Frontiers in global women's health · 2026Article
- The impact of maternal chronic stress on spontaneous preterm birth: evidence from a Chinese cohort study.BMC pregnancy and childbirth · 2025Article
- Associations Between Racial Residential Segregation and Hypertensive Disorders of Pregnancy among Black women: The Coronary Artery Risk Development in Young Adults Study.International journal of cardiology. Cardiovascular risk and prevention · 2025Article
- Association of maternal nocturnal heart rate and adverse pregnancy outcomes.Pregnancy (Hoboken, N.J.) · 2025Article
- The role of allostatic load in adverse pregnancy outcomes: a multisystem, developmental perspective.Frontiers in global women's health · 2025Review
- Association of pregnancy complications and postpartum maternal leukocyte telomeres in two diverse cohorts: a nested case-control study.BMC pregnancy and childbirth · 2024Article
- Association of allostatic load with overall survival in epithelial ovarian cancer.Gynecologic oncology · 2024Observational
- Trends and Disparities in Severe Maternal Morbidity Indicator Categories during Childbirth Hospitalization in California from 1997 to 2017.American journal of perinatology · 2024Article
- Observational
- Navigating Homelessness Assistance While Pregnant: A Rapid Qualitative Research-to-Policy Collaboration in Washington, DC.Health equity · 2024Article
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
objectiveTo assess the association between allostatic load, as an estimate of chronic stress, and adverse pregnancy outcomes.
methodsThis was a secondary analysis of nuMoM2b (Nulliparous Pregnancy Outcomes Study: Monitoring Mothers-to-Be), a prospective observational cohort study. Our primary exposure was dichotomous high allostatic load in the first trimester, defined as 4 or more of 12 biomarkers in the "worst" quartile. The primary outcome was a composite adverse pregnancy outcome: hypertensive disorders of pregnancy (HDP), preterm birth, small for gestational age (SGA), and stillbirth. Secondary outcomes included components of the composite. Multivariable logistic regression was used to test the association between high allostatic load and adverse pregnancy outcomes, adjusted for potential confounders. Mediation and moderation analyses were conducted to assess the role of allostatic load along the causal pathway between racial disparities and adverse pregnancy outcomes.
resultsAmong 4,266 individuals, 34.7% had a high allostatic load. Composite adverse pregnancy outcome occurred in 1,171 (27.5%): 14.0% HDP, 8.6% preterm birth (48.0% spontaneous and 52.2% indicated), 11.0% SGA, and 0.3% stillbirth. After adjustment for maternal age, gravidity, smoking, bleeding in the first trimester, and health insurance, high allostatic load was significantly associated with a composite adverse pregnancy outcome (adjusted odds ratio [aOR] 1.5, 95% CI 1.3, 1.7) and HDP (aOR 2.5, 95% CI 2.0-2.9), but not preterm birth or SGA. High allostatic load partially mediated the association between self-reported race and adverse pregnancy outcomes. The association between allostatic load and HDP differed by self-reported race, but not for a composite adverse pregnancy outcome, preterm birth, or SGA.
conclusionHigh allostatic load in the first trimester is associated with adverse pregnancy outcomes, particularly HDP. Allostatic load was a partial mediator between race and adverse pregnancy outcomes. The association between allostatic load and HDP differed by self-reported race.
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