ArticleBMC endocrine disorders2022
Relationship between a novel non-insulin-based metabolic score for insulin resistance (METS-IR) and coronary artery calcification.
Article in BMC endocrine disorders, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 2 syntheses or guidelines pooled it, 40 citations in OpenAlex.
- Metabolic score for insulin resistance and the incidence of cardiovascular disease: a meta-analysis of cohort studies.Frontiers in endocrinology · 2025Pooled it
- Association between the homeostasis model assessment of insulin resistance and coronary artery calcification: a meta-analysis of observational studies.Frontiers in endocrinology · 2023Pooled it
- Usefulness of metabolic score for insulin resistance to predict restenosis after coronary stent implantation.Annals of medicine · 2026Article
- Association between metabolic score for insulin resistance and risk of cardiometabolic multimorbidity: an analysis based on two national prospective cohorts.Nutrition & metabolism · 2026Article
- Chinese visceral adiposity index outperforms insulin resistance indices in predicting cardiovascular disease risk: a 12-year prospective cohort study.Frontiers in nutrition · 2026Article
- Triglyceride-glucose index is associated with the severity of coronary artery disease.PloS one · 2026Article
- Article
- Surrogate markers of insulin resistance and coronary artery disease in type 2 diabetes: U-shaped TyG association and insights from machine learning integration.Lipids in health and disease · 2025Article
- Article
- Triglyceride-glucose index as a superior marker of insulin resistance for predicting long-term major adverse cardiovascular events following coronary artery bypass grafting in China.Scientific reports · 2025Article
- Relationship of METS-IR with cardiometabolic multimorbidity in China: a nationwide longitudinal cohort study.Frontiers in nutrition · 2025Article
- The association between TyG index and hypertension in middle-aged and elderly Chinese patients: Data from CHALRS.PloS one · 2025Article
- Association of non-insulin-dependent insulin resistance indices with lower limb artery restenosis after drug-coated balloon angioplasty.Lipids in health and disease · 2024Article
- Exploring the Relationship Between Visceral Fat and Coronary Artery Calcification Risk Using Metabolic Score for Visceral Fat (METS-VF).Life (Basel, Switzerland) · 2024Article
- A linear positive association between high-sensitivity C-reactive protein and the prevalence of cardiovascular disease among individuals with diabetes.BMC cardiovascular disorders · 2024Article
- Association between metabolic score for insulin resistance and clinical outcomes: insights from the Tehran lipid and glucose study.Nutrition & metabolism · 2024Article
- Association of non-insulin-based insulin resistance indices with disease severity and adverse outcome in idiopathic pulmonary arterial hypertension: a multi-center cohort study.Cardiovascular diabetology · 2024Article
- Relationship between TyG index and the degree of coronary artery lesions in patients with H-type hypertension.Cardiovascular diabetology · 2024Article
- The association between the metabolic score for insulin resistance and mortality in patients with cardiovascular disease: a national cohort study.Frontiers in endocrinology · 2024Article
- Adipocentric origin of the common cardiometabolic complications of obesity in the young up to the very old: pathophysiology and new therapeutic opportunities.Frontiers in medicine · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
aimsA novel non-insulin-based metabolic score for insulin resistance (METS-IR) index has been proposed as a simple and reliable alternative insulin resistance (IR) marker, but its the predictive value in asymptomatic adults with coronary artery calcification (CAC) remains unclear. METHODS AND
resultsWe enrolled 1576 participants without cardiovascular disease (CVD), who underwent multidetector computed tomography. Logistic regression, restricted cubic spline models and receiver operating characteristic (ROC) curves were used to examine the association between METS-IR, the ratio of triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) and triglyceride glucose index (TyG index) and CAC. In multivariate logistic regression analysis, the increase in METS-IR was independently associated with a higher prevalence of CAC (all P < 0.05 in Models 1-3). Furthermore, restricted cubic splines indicated that the significance of METS-IR in predicting CAC was higher than that of other IR indexes. In ROC curve analysis, without considering the P value, the area under the curve of CAC predicted by METS-IR was higher than that of other IR indexes (METS-IR, 0.607; TyG index, 0.603; TG/HDL-C, 0.577).
conclusionCompared with other IR indexes, METS-IR may have better discrimination ability in predicting the incidence of CAC in asymptomatic adults without CVD.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.