Observational studyBMC pregnancy and childbirth2022
Pregnancy outcomes and risk factors for preeclampsia in dichorionic twin pregnancies after in vitro fertilization: a five-year retrospective study.
Observational study in BMC pregnancy and childbirth, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 2 of them syntheses that pooled it.
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Who cites it
10 citing papers in PubMed, 2 syntheses or guidelines pooled it, 11 citations in OpenAlex.
- Global and regional incidence of intrahepatic cholestasis of pregnancy: a systematic review and meta-analysis.BMC medicine · 2025Pooled it
- Maternal and neonatal outcomes of dichorionic twin pregnancies achieved with assisted reproductive technology: meta-analysis of contemporary data.Journal of assisted reproduction and genetics · 2024Pooled it
- First-trimester preeclampsia prediction model via integrative machine learning of maternal risk profiles and laboratory markers.Genes & diseases · 2026Article
- Resolution of Preeclampsia After Single Selective Termination in Twins: A Case Series and Literature Review.Clinical case reports · 2026Article
- Obstetrical and Neonatal Outcomes in Twin Pregnancies Based on Chorionicity: A Systematic Review of ART-Conceived Monochorionic vs. Dichorionic Twins.Journal of clinical medicine · 2026Review
- Comparative Predictive Value of First-Trimester Crown-Rump Length and Nuchal Translucency Discordance for Fetal Growth Restriction in Twin Pregnancies: A Retrospective Cohort Study.Journal of clinical medicine · 2026Article
- Association betweenFrontiers in endocrinology · 2026Observational
- Prevalence, risk factors, and adverse perinatal outcomes in Chinese women with preeclampsia: a large retrospective cohort study.Journal of health, population, and nutrition · 2025Article
- Analysis of serological risk factors for preeclampsia and the predictive role of high homocysteine levels.American journal of translational research · 2025Article
- Early age at menarche is associated with an increased risk of preeclampsia and adverse neonatal outcomes: a 6‑year retrospective study.Archives of gynecology and obstetrics · 2024Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBoth in vitro fertilization (IVF) and preeclampsia (PE) were associated with placental dysfunction. Although IVF can increase the incidence of PE, the pregnancy outcomes and risk factors for preeclampsia in dichorionic twin pregnancies conceived via IVF remain unclear. This study aimed to investigate the pregnancy outcomes and the risk factors for preeclampsia in dichorionic twin pregnancies conceived through IVF compared to those conceived after natural conception (NC).
methodsThis retrospective observational study enrolled 181 dichorionic twin pregnancy women with preeclampsia from 2016 to 2020. According to the mode of conception, they were allocated into IVF (n = 117) and NC groups (n = 64). The clinical characteristics of preeclampsia and pregnancy outcomes between the two groups were compared by using Student's t test, chi-square test, and Fisher's exact test, and logistic regression models were used to obtain adjusted odds ratios (aOR) with 95% confidence intervals (CI) for risk factors of early-onset preeclampsia.
resultsThe incidence of early-onset PE and growth discordance in dichorionic twin pregnancies with PE is significantly higher in IVF-PE group than in NC group (78.60% vs 43.80%, P < 0.001, 11.10% vs 25.00%, P = 0.015). We found that IVF (aOR = 4.635, 95% CI: 2.130-10.084, P < 0.001) and growth discordance (aOR = 3.288; 95% CI: 1.090-9.749, P < 0.05) increased the incidence of early-onset PE.
conclusionsIn preeclamptic dichorionic twin pregnancies, IVF and growth discordance were associated with the increased incidence of early-onset PE. The underlying mechanism for the relationship between IVF and early-onset PE or growth discordance may be placental dysfunction.
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