ArticleNature neuroscience2022
Long-term stability of single neuron activity in the motor system.
Article in Nature neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
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Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it, 51 citations in OpenAlex.
- Connectomic Mapping of Chronic Musculoskeletal Pain: Neural Circuitries Identified Through a Systematic Review and ALE Meta-Analysis.Neural plasticity · 2026Pooled it
- Realignment of representational drift in mouse visual cortex via flexible electrode arrays.Nature biomedical engineering · 2026Article
- Density-based longitudinal neuron tracking in high-density electrophysiological recordings.Patterns (New York, N.Y.) · 2026Article
- Ethological learning during the critical period resets synaptic setpoints in mouse binocular visual cortex.Neuron · 2026Article
- Learning shapes neural codes for sensory-motor integration in the tail of the striatum.bioRxiv : the preprint server for biology · 2026Article
- A complex network perspective on brain disease.Biological reviews of the Cambridge Philosophical Society · 2026Review
- Single-Field Evolution Rule Governs the Dynamics of Representational Drift in Mouse Hippocampal Dorsal CA1 Region.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Long-term neuron tracking reveals balance of stability and plasticity in functional properties.PloS one · 2026Article
- Pre-existing and emergent cortical neuronal assembly sequences during learning.bioRxiv : the preprint server for biology · 2025Article
- Article
- Temporal coding carries more stable cortical visual representations than firing rate over time.Nature communications · 2025Article
- The Role of Striatum in Controlling Waiting during Reactive and Self-Timed Behaviors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Rapid prey capture learning drives a slow resetting of network activity in rodent binocular visual cortex.bioRxiv : the preprint server for biology · 2025Article
- Tracking neurons across days with high-density probes.Nature methods · 2025Article
- Compensatory Regulation of Excitation/Inhibition Balance in the Ventral Hippocampus: Insights from Fragile X Syndrome.Biology · 2025Review
- Article
- Sensory experience steers representational drift in mouse visual cortex.Nature communications · 2024Article
- Perpetual step-like restructuring of hippocampal circuit dynamics.Cell reports · 2024Article
- Differential stability of task variable representations in retrosplenial cortex.Nature communications · 2024Article
- Multi-day neuron tracking in high-density electrophysiology recordings using earth mover's distance.eLife · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 3 countries.
Funding
Abstract
How an established behavior is retained and consistently produced by a nervous system in constant flux remains a mystery. One possible solution to ensure long-term stability in motor output is to fix the activity patterns of single neurons in the relevant circuits. Alternatively, activity in single cells could drift over time provided that the population dynamics are constrained to produce the same behavior. To arbitrate between these possibilities, we recorded single-unit activity in motor cortex and striatum continuously for several weeks as rats performed stereotyped motor behaviors-both learned and innate. We found long-term stability in single neuron activity patterns across both brain regions. A small amount of drift in neural activity, observed over weeks of recording, could be explained by concomitant changes in task-irrelevant aspects of the behavior. These results suggest that long-term stable behaviors are generated by single neuron activity patterns that are themselves highly stable.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.