ArticleNature microbiology2022
Divergent SARS-CoV-2 variant emerges in white-tailed deer with deer-to-human transmission.
Article in Nature microbiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 157 papers, 1 of them a synthesis that pooled it.
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Who cites it
157 citing papers in PubMed, 1 synthesis or guideline pooled it, 232 citations in OpenAlex.
- Systematic Review and Meta-Analysis of Emerging Viral Zoonotic Diseases, 2016-2026.Transboundary and emerging diseases · 2026Pooled it
- Breadth of ACE2 receptor usage predicts host range and antigenic relatedness across bat sarbecoviruses.PLoS biology · 2026Article
- From sites to structure to serology: a roadmap for structure-aware molecular evolution of antigenically evolving viruses.Journal of virology · 2026Review
- How do anthropogenic changes affect wildlife microbiomes?PLoS biology · 2026Article
- SARS-CoV-2 Delta variant re-emerges in US farmed mink and free-ranging white-tailed deer in 2022-2023.Nature communications · 2026Article
- Serological investigation of zoo animals: SARS-CoV-2 antibodies detected in a European moose and an Asian golden cat.One health outlook · 2026Article
- Article
- Narrowed host ranges do not constrain future host range expansion in RNA phage Φ6.Journal of virology · 2026Article
- Screening of wild roe deer populations in Sweden 2016-2022 for SARS-CoV-2.One health (Amsterdam, Netherlands) · 2026Article
- A global-scale assessment of zoonotic virus diversity and spillover potential in urban-adapted mammal species.Nature microbiology · 2026Article
- Species- and variant-specific ACE2 compatibility shapes SARS-CoV-2 spillover potential in North American cervids.Nature communications · 2026Article
- Serological Survey of SARS-CoV-2 in Wild Canids in Serbia: First Report in Red Foxes and Golden Jackals.Veterinary sciences · 2026Article
- Molecular basis of fox ACE2 recognition by receptor binding domains of SARS-CoV-2 and PCoV-GD.Cell insight · 2026Article
- Structural Constraints Acting on the SARS-CoV-2 Spike Protein Reveal Limited Space for Viral Adaptation.Genome biology and evolution · 2026Article
- Will animal reservoirs give us the next SARS-CoV-2 variant?PLoS pathogens · 2026Article
- SARS-CoV-2 occurrence in cervids in the United States and US territories.Scientific reports · 2026Article
- Impact of prolonged infection on SARS-CoV-2 evolution.Microbiology spectrum · 2026Article
- Chronic infections can generate SARS-CoV-2-like bursts of viral evolution without epistasis.Virus evolution · 2026Article
- Seroprevalence of SARS-CoV-2 in Livestock in Sarawak, East Malaysia.Transboundary and emerging diseases · 2026Article
- The coronaviral landscape across diverse mammalian species in the Northeastern United States.Scientific reports · 2025Article
97 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on byViral spillback.2023
- Erratum issued
Authors and funding
40 authors at 13 institutions in 2 countries.
Funding
Abstract
Wildlife reservoirs of broad-host-range viruses have the potential to enable evolution of viral variants that can emerge to infect humans. In North America, there is phylogenomic evidence of continual transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) from humans to white-tailed deer (Odocoileus virginianus) through unknown means, but no evidence of transmission from deer to humans. We carried out an observational surveillance study in Ontario, Canada during November and December 2021 (n = 300 deer) and identified a highly divergent lineage of SARS-CoV-2 in white-tailed deer (B.1.641). This lineage is one of the most divergent SARS-CoV-2 lineages identified so far, with 76 mutations (including 37 previously associated with non-human mammalian hosts). From a set of five complete and two partial deer-derived viral genomes we applied phylogenomic, recombination, selection and mutation spectrum analyses, which provided evidence for evolution and transmission in deer and a shared ancestry with mink-derived virus. Our analysis also revealed an epidemiologically linked human infection. Taken together, our findings provide evidence for sustained evolution of SARS-CoV-2 in white-tailed deer and of deer-to-human transmission.
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