ArticleNature medicine2022
Rare and common genetic determinants of metabolic individuality and their effects on human health.
Abstract read
In one paragraph
Article in Nature medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 103 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
103citing papers in PubMed, 2 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
103 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Pooled it
- Cross-ancestry analyses of Chinese and European populations reveal insights into the genetic architecture and disease implication of metabolites.Cell genomics · 2025Pooled it
- Genetic Variation in Response to the Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND): A Randomized Controlled Trial.Nutrients · 2026Trial
- A Multi-Omic Mosaic Model of Acetaminophen Induced Alanine Aminotransferase Elevation.Journal of medical toxicology : official journal of the American College of Medical Toxicology · 2023Trial
- Mapping the causal chain from genetic risk variants to lipid dysmetabolism in Parkinson's disease.Brain : a journal of neurology · 2026Article
- Multimodal deep learning enhances genomic risk prediction for cardiometabolic diseases.Briefings in bioinformatics · 2026Article
- Steroid 5α-reductases in the brain: From neurosteroidogenesis to therapeutic implications.Frontiers in neuroendocrinology · 2026Review
- Genome-wide association studies of missing metabolite measures from two population-based studies.Genome biology · 2026Article
- The blood metabolome of brain health in midlife and influences of genes, microbiome and exposome.Nature aging · 2026Article
- Analysis of whole genome sequencing and plasma metabolomics unveil genetic determinants and clinical implications for human health.Nature communications · 2026Article
- A genetic atlas of relationships between circulating metabolites and liability to psychiatric conditions.Molecular psychiatry · 2026Article
- Article
- African ancestry-enriched variants in the GATM gene are associated with elevated serum creatinine levels.Genome medicine · 2026Article
- Blood biomarkers and breed genetics of aging in pet dogs.bioRxiv : the preprint server for biology · 2026Article
- Hypothesis-free evaluation of circulating metabolome provides cell-specific insights regarding the role of energy substrate availability in amyotrophic lateral sclerosis.BMC medicine · 2026Article
- Genetic variations interact with polybrominated diphenyl ether exposure to alter lipid homeostasis.Nature communications · 2026Article
- Genetic co-regulation of neopterin and Parkinson's disease.NPJ Parkinson's disease · 2026Article
- Genetic regulation of fatty acid content in adipose tissue.American journal of human genetics · 2026Article
- Circulating metabolites, genetics and lifestyle factors in relation to future risk of type 2 diabetes.Nature medicine · 2026Article
- Integration of metabolomic and genetic data reveals novel variants underpinning the human metabolome: the Coronary Artery Risk Development in Young Adults (CARDIA) study.medRxiv : the preprint server for health sciences · 2026Article
43 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
Authors and funding
36 authors.
Praveen Surendran *British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Isobel D Stewart *MRC Epidemiology Unit, University of Cambridge, Cambridge, UK.
Victoria P W Au YeungMRC Epidemiology Unit, University of Cambridge, Cambridge, UK.
Maik PietznerMRC Epidemiology Unit, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0003-3437-9963
Johannes RafflerInstitute of Computational Biology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
Maria A WörheideInstitute of Computational Biology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.ORCID http://orcid.org/0000-0002-9326-7227
Chen LiMRC Epidemiology Unit, University of Cambridge, Cambridge, UK.
Rebecca F SmithBritish Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Laura B L WittemansMRC Epidemiology Unit, University of Cambridge, Cambridge, UK.
Lorenzo BombaDepartment of Human Genetics, Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK.
Cristina MenniDepartment of Twin Research & Genetic Epidemiology, King's College London, London, UK.ORCID http://orcid.org/0000-0001-9790-0571
Jonas ZiererDepartment of Twin Research & Genetic Epidemiology, King's College London, London, UK.ORCID http://orcid.org/0000-0002-9693-1859
Niccolò RossiDepartment of Twin Research & Genetic Epidemiology, King's College London, London, UK.
Patricia A SheridanMetabolon, Morrisville, NC, USA.
Nicholas A WatkinsNHS Blood and Transplant, Cambridge Biomedical Campus, Cambridge, UK.
Massimo ManginoDepartment of Twin Research & Genetic Epidemiology, King's College London, London, UK.ORCID http://orcid.org/0000-0002-2167-7470
Pirro G HysiDepartment of Twin Research & Genetic Epidemiology, King's College London, London, UK.
Emanuele Di AngelantonioBritish Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Mario FalchiDepartment of Twin Research & Genetic Epidemiology, King's College London, London, UK.ORCID http://orcid.org/0000-0002-5646-1004
Tim D SpectorDepartment of Twin Research & Genetic Epidemiology, King's College London, London, UK.ORCID http://orcid.org/0000-0002-9795-0365
Nicole SoranzoBritish Heart Foundation Centre of Research Excellence, School of Clinical Medicine, Addenbrooke's Hospital, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0003-1095-3852
Gregory A MichelottiMetabolon, Morrisville, NC, USA.ORCID http://orcid.org/0000-0002-3936-4675
Wiebke ArltInstitute of Metabolism and Systems Research, University of Birmingham, Birmingham, UK.ORCID http://orcid.org/0000-0001-5106-9719
Luca A LottaMRC Epidemiology Unit, University of Cambridge, Cambridge, UK.
Spiros DenaxasInstitute of Health Informatics, University College London, London, UK.
Harry HemingwayInstitute of Health Informatics, University College London, London, UK.
Eric R GamazonVanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN, USA.
Joanna M M HowsonBritish Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0001-7618-0050
Angela M WoodBritish Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
John DaneshBritish Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Nicholas J WarehamHealth Data Research UK Cambridge, Wellcome Genome Campus and University of Cambridge, Hinxton, UK.ORCID http://orcid.org/0000-0003-1422-2993
Gabi KastenmüllerInstitute of Computational Biology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.ORCID http://orcid.org/0000-0002-2368-7322
Eric B FaumanInternal Medicine Research Unit, Pfizer Worldwide Research, Development and Medical, Cambridge, MA, USA.ORCID http://orcid.org/0000-0002-9739-0249
Karsten SuhreDepartment of Biophysics and Physiology, Weill Cornell Medicine-Qatar, Doha, Qatar.
Adam S ButterworthBritish Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK. asb38@medschl.cam.ac.uk.ORCID http://orcid.org/0000-0002-6915-9015
Claudia LangenbergMRC Epidemiology Unit, University of Cambridge, Cambridge, UK. Claudia.Langenberg@mrc-epid.cam.ac.uk.ORCID http://orcid.org/0000-0002-5017-7344
Funding
Project 4 - Mechanistic studies on the role of the gut microbiome in models for Alzheimer's diseaseU19AG063744 · NIA · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI ROB KNIGHT, Rima F Kaddurah-Daouk · 2019 to 2026
$54.1MMetabolomic Signatures for Disease Sub-classification and Target Prioritization in AMP-ADU01AG061359 · NIA · DUKE UNIVERSITY · PI KADDURAH-DAOUK, RIMA F, KASTENMULLER, GABI · 2018 to 2022
$10.0MMetabolic Networks and Pathways Predictive of Sex Differences in AD Risk and Responsiveness to TreatmentRF1AG059093 · NIA · DUKE UNIVERSITY · PI BRINTON, ROBERTA EILEEN, CHANG, RUI · 2018 to 2018
$5.9MMetabolic Network Analysis of Biochemical Trajectories in Alzheimer's DiseaseRF1AG057452 · NIA · DUKE UNIVERSITY · PI KADDURAH-DAOUK, RIMA F, KASTENMULLER, GABI · 2017 to 2017
$3.5MHaplotype-aware models of gene and isoform expression with application to genetic studies of disease in diverse populationsR01GM140287 · NIGMS · SEATTLE CHILDREN'S HOSPITAL · PI GAMAZON, ERIC R, MOHAMMADI, PEJMAN · 2021 to 2024
$2.8MFunctional Genomics: A Phenome-wide SurveyR35HG010718 · NHGRI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI GAMAZON, ERIC R · 2019 to 2023
$2.2MAdvancing Multi-Omics and Electronic Health Records Computational MethodologiesR01HG011138 · NHGRI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI GAMAZON, ERIC R · 2020 to 2024
$1.6MAdvancing drug repositioning and development for Alzheimer's Disease using functional genomics and computational phenomicsR56AG068026 · NIA · VANDERBILT UNIVERSITY MEDICAL CENTER · PI GAMAZON, ERIC R · 2021 to 2022
$1.5MBritish Heart Foundation AA/18/6/24223British Heart Foundation BCDSA\100005British Heart Foundation CH/12/2/29428British Heart Foundation RG/13/13/30194British Heart Foundation RG/18/13/33946British Heart Foundation SP/09/002Cancer Research UK 14136Cancer Research UK C864/A14136Department of Health BRC-1215-20009Department of Health BRC-1215-20014Department of Health BTRU-2014-10024Medical Research Council G0401527Medical Research Council G1000143Medical Research Council MC_PC_13048Medical Research Council MC_PC_17228Medical Research Council MC_QA137853Medical Research Council MC_UU_00006/1Medical Research Council MC-UU_12015/1Medical Research Council MC_UU_12015/1Medical Research Council MR/L00002/1Medical Research Council MR/L003120/1Medical Research Council MR/N003284/1Medical Research Council MR/S003746/1NHGRI NIH HHS R01 HG011138NHGRI NIH HHS R35 HG010718NIA NIH HHS R56 AG068026NIA NIH HHS RF1 AG057452NIA NIH HHS RF1 AG059093NIA NIH HHS U01 AG061359NIA NIH HHS U19 AG063744NIGMS NIH HHS R01 GM140287Wellcome TrustWellcome Trust 203810/Z/16/AWellcome Trust 206194Wellcome Trust 221651/Z/20/ZWellcome Trust WT209492/Z/17/Z
Abstract
Garrod's concept of 'chemical individuality' has contributed to comprehension of the molecular origins of human diseases. Untargeted high-throughput metabolomic technologies provide an in-depth snapshot of human metabolism at scale. We studied the genetic architecture of the human plasma metabolome using 913 metabolites assayed in 19,994 individuals and identified 2,599 variant-metabolite associations (P < 1.25 × 10
Indexed as
Metabolism, Inborn ErrorsMetabolome3-Oxo-5-alpha-Steroid 4-DehydrogenaseHumansMembrane ProteinsMetabolomicsPhenotypePlasma3-Oxo-5-alpha-Steroid 4-DehydrogenaseMembrane ProteinsSRD5A2 protein, human
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.