ArticleScientific reports2022
Corneal elastic property investigated by terahertz technology.
Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
7 citing papers in PubMed, 15 citations in OpenAlex.
- Birefringence of the Human Cornea: A Review.Vision (Basel, Switzerland) · 2025Review
- Time-dependent changes in corneal biomechanics after small incision lenticule extraction: an in vivo study.BMC ophthalmology · 2025Article
- The Application of Terahertz Technology in Corneas and Corneal Diseases: A Systematic Review.Bioengineering (Basel, Switzerland) · 2025Review
- Is Ortho-Terphenyl a Rigid Glass Former?The journal of physical chemistry letters · 2024Article
- Study of Elastic and Structural Properties of BaFeMaterials (Basel, Switzerland) · 2023Article
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Corrections and comments
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
Abstract
Terahertz (THz) spectroscopy technique has been applied in ex vivo biomechanical properties analysis of human corneas. Upon the application of light pressure on the cornea, the photo elastic birefringent effect, anisotropic deformation, thickness changes and hydration levels will contribute to the sudden phase changes of terahertz time domain signal. The shelf lifetime study shows that the phase shift is reduced and cornea loose the biomechanical properties with the increase of hydration level. Mechanical behaviors have been further studied based on the "fresh" cut corneas with the similar hydration levels. THz signal was collected by focusing inside of the cornea to avoid the phase shift due to light stress caused movement of the corneal surface. By this way, the amount of THz signal refractive index variation is correlated to the elastic property of the corneas. The correlation between the THz signal phase shift and refractive index shift due to the corneal strain can be used to derive the elastic Young's modulus. Our results demonstrated the THz spectroscopy, as a non-contact and non-invasive detection method, could be potential for understanding the mechanism of corneal deformation under the action of intraocular pressure in the physiological environment in future.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.