SynthesisScientific reports2022
Secondary caries and marginal adaptation of ion-releasing versus resin composite restorations: a systematic review and meta-analysis of randomized clinical trials.
Synthesis in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Clinical effectiveness of ion-releasing restorations compared to composite restorations in pediatric dental treatments: a systematic review and meta-analysis.Frontiers in dental medicine · 2025Pooled it
- Clinical effectiveness of pit and fissure sealants in primary and permanent teeth of children and adolescents: an umbrella review.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2024Pooled it
- A two-year randomized clinical trial of bulk-fill and ion-releasing composites with universal adhesives in class V carious lesions.Clinical oral investigations · 2026Trial
- Clinical performance and cost-effectiveness of low-shrinkage giomer resin composite versus resin-modified glass ionomer in cervical carious lesions: a 12-month randomized controlled trial.BMC oral health · 2025Trial
- Assessment of Chemical, Mechanical, and Microscopic Properties of Novel Self-Adhesive Dental Composites.European journal of dentistry · 2026Article
- How does thermocycling affect the surface properties of ion-releasing bulk‑fill resin composites?European journal of oral sciences · 2026Article
- Cariogenic Risk Modifies the Effect of Marginal Adaptation on Caries Adjacent to Posterior Composite Restorations: A Stratified Multivariate Analysis.Clinics and practice · 2026Article
- Recent Advances in Caries Prevention and Non-Invasive Management: From Ecological Modulation to Precision Interventions.Dentistry journal · 2026Review
- In vitro evaluation of a novel self-adhesive composite primer modified with nano zinc oxide and hydroxyapatite: antibacterial activity, marginal microleakage, and interfacial elemental analysis.BMC oral health · 2026Article
- Getting your publication right - Part 2 - Structuring a research manuscript: A guide to writing a case report.Journal of conservative dentistry and endodontics · 2026Review
- The Cariostatic Mechanisms of Fluoride-An Updated Review.Dentistry journal · 2026Review
- Long-Term Clinical Performance of Posterior Composite Restorations After Nearly Three Decades: A Clinical Follow-Up Study.Dentistry journal · 2026Article
- Article
- Optimizing Dental Resin-Based Composite Polymerization with Distance and Exposure Variables: Preliminary Study.Materials (Basel, Switzerland) · 2026Article
- Bioactive and Ion-releasing materials in minimum intervention dentistry: a clinical pathway from prevention to restorative treatment.Frontiers in dental medicine · 2026Article
- Prediction of marginal adaptation failure in restorations of non-carious cervical lesions, based on machine learning.Brazilian oral research · 2025Article
- Clinical Effectiveness of Ion-Releasing Restorations versus Composite Restorations in Dental Restorations: Systematic Review and Meta-Analysis.Dentistry journal · 2024Review
- Retrospective Clinical Evaluation of RMGIC/GIC Class V Restorations.Dentistry journal · 2023Article
- Intramedullary bone tissue reaction of ion-releasing resin-modified glass-ionomer restoration versus two calcium silicate-based cements: an animal study.Scientific reports · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This systematic review was aimed to evaluate occurrence of secondary caries and marginal adaptation in ion-releasing materials versus resin composite. Electronic search of PubMed, Scopus, and Open Grey databases with no date or language restrictions until May 21st, 2021, was conducted. Randomized clinical trials that compared ion-releasing restorations versus resin composite were included. For quantitative analysis, a random-effects meta-analysis with risk difference as an effect measure and a 95% confidence interval was used. Quality of evidence was assessed using The Grading of Recommendations, Assessment, Development, and Evaluation criteria. The risk of bias was evaluated using the Cochran Collaboration Risk of Bias tool. The inclusion criteria were met by 22 studies, and 10 studies were included in the meta-analysis. Three follow-up periods (1 year, 18 months-2 years, and 3 years) were evaluated. The overall quality of evidence for secondary caries and marginal adaptation outcomes was low. The results of the meta-analysis showed no significant difference (p > 0.05) in both outcomes between ion-releasing materials and resin composite. The occurrence of secondary caries was not dependent on the nature of the restorative material. It is more likely a complex process that involves the same risk factors as primary carious lesions.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.