Evidence map›Paper›PMID 36357447›Full record

ArticleScientific reports2022

Isolongifolene-loaded chitosan nanoparticles synthesis and characterization for cancer treatment.

Dharmar Manimaran, Namasivayam Elangovan, Panagal Mani, Kumaran Subramanian, Daoud Ali, Saud Alarifi, Chella Perumal Palanisamy, Hongxia Zhang, Kowsalya Rangasamy, Vasan Palanisamy and 6 more

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 33 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 10 institutions in 5 countries.

Dharmar ManimaranDepartment of Biotechnology, School of Biosciences, Periyar University, Salem, Tamil Nadu, 636011, India.
Namasivayam ElangovanDepartment of Biotechnology, School of Biosciences, Periyar University, Salem, Tamil Nadu, 636011, India.
Panagal ManiDepartment of Biotechnology, Annai College of Arts and Science, Kumbakonam, Tamil Nadu, India. master.maniji@gmail.com.
Kumaran SubramanianCentre for Drug Discovery and Development, Sathyabama Institute of Science and Technology, Chennai, Tamilnadu, 600119, India. kumarun23@gmail.com.
Daoud AliDepartment of Zoology, College of Science, King Saud University, PO Box2455, Riyadh, 11451, Saudi Arabia.
Saud AlarifiDepartment of Zoology, College of Science, King Saud University, PO Box2455, Riyadh, 11451, Saudi Arabia.
Chella Perumal PalanisamyState Key Laboratory of Biobased Materials and Green Paper Making, School of Food Science and Engineering, Qilu University of Technology, Shandong Academy of Sciences, Jinan, Shandong, People's Republic of China.
Hongxia ZhangState Key Laboratory of Biobased Materials and Green Paper Making, School of Food Science and Engineering, Qilu University of Technology, Shandong Academy of Sciences, Jinan, Shandong, People's Republic of China.
Kowsalya RangasamyDepartment of Biotechnology, School of Biosciences, Periyar University, Salem, Tamil Nadu, 636011, India.
Vasan PalanisamyDepartment of Animal Nutrition, Veterinary College and Research Institute, Tamil Nadu Veterinary and Animal Sciences University, Namakkal, 637 002, India.
Renuka ManiDepartment of Biotechnology, School of Biosciences, Periyar University, Salem, Tamil Nadu, 636011, India.
Kavitha GovarthananStem Cell and Molecular Biology Lab, Department of Biotechnology, Bhupat and Jyoti Mehta School of Biosciences, Indian Institute of Technology Madras, Chennai, 600036, India.
Wilson AruniAmity University, Mumbai, India.
Rajeshkumar ShanmugamNanobiomedicine Lab, Department of Pharmacology, Saveetha Institute of Medical and Technical Sciences, Saveetha Dental College, Chennai, Tamil Nadu, India.
Guru Prasad SrinivasanCentre for Materials Engineering and Regenerative Medicine, Bharath Institute of Higher Education and Research (BIHER), Chennai, India.
Aruncahllam KalirajanDepartment of Chemistry and Biology, School of Natural and Applied Sciences, Mulungushi University, 80415, Kabwe, Zambia. akalirajan@mu.edu.zm.
Periyar University · INKing Saud University · SAShandong Academy of Sciences · CNTamil Nadu Veterinary and Animal Sciences University · INBharath University · INIndian Institute of Technology Madras · INMulungushi University · ZMSathyabama Institute of Science and Technology · INSaveetha University · INVA Loma Linda Healthcare System · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recent breakthroughs in the field of nanoparticle-based therapeutic delivery methods have changed the standpoint of cancer therapy by effectively delaying the process of disease development. Nanoparticles have a unique capacity of good penetrating ability than other therapeutic leads used in traditional therapeutics, and also, they have the highest impact on disease management. In the current study isolongifolene-loaded Chitosan nanoparticles have been formulated, synthesized and then characterized by the use of Fourier Transform Infrared Spectroscopy, X-ray Diffraction, Scanning Electron Microscopy and Transmission Electron Microscopy. Further, the characterized chitosan nano formulation was evaluated for hemocompatibility, plasma stability, and in-vitro release. Isolongifolene-loaded chitosan nanoparticles were found to be compatible with plasma and also, they exhibited a constant release pattern. Hence, chitosan-loaded nanoparticles could be employed as an excellent adjuvant in cancer therapeutic, to combat the multi-drug resistance in solid tumors.

Indexed as

ChitosanNanoparticlesNeoplasmsDrug CarriersMicroscopy, Electron, ScanningMicroscopy, Electron, TransmissionParticle SizeSpectroscopy, Fourier Transform InfraredX-Ray DiffractionChitosanDrug Carriers

Identifiers

PMID36357447
PMCPMC9649682
OpenAlexW4308885891

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.