ArticleJACC. Cardiovascular imaging2022
Plaque Burden and 1-Year Outcomes in Acute Chest Pain: Results From the Multicenter RAPID-CTCA Trial.
Article in JACC. Cardiovascular imaging, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02284191 (The Role of Early CT Coronary Angiography in the Evaluation, Intervention and Outcome of Patients Presenting to the Emergency Department With Suspected or Confirmed Acute Coronary Syndrome.), which is not on this map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Role of Early CT Coronary Angiography in the Evaluation, Intervention and Outcome of Patients Presenting to the Emergency Department With Suspected or Confirmed Acute Coronary Syndrome.
Who cites it
20 citing papers in PubMed, 43 citations in OpenAlex.
- Redefining NSTE-ACS risk assessment: The synergistic power of CT-enhanced GRACE 2.0 score for advanced prognosis.The international journal of cardiovascular imaging · 2026Article
- Association of Low-Attenuation Noncalcified Plaque Shape and Degree of Intraplaque Embeddedness Using Atherosclerotic Imaging-enabled Quantitative CT with Acute Coronary Syndrome.Radiology. Cardiothoracic imaging · 2026Article
- Deep Learning-based Automated Coronary Plaque Quantification: First Demonstration With Ultra-high Resolution Photon-counting Detector CT at Different Temporal Resolutions.Investigative radiology · 2026Article
- Coronary CT angiography evaluation with artificial intelligence for individualized medical treatment of atherosclerosis: a Consensus Statement from the QCI Study Group.Nature reviews. Cardiology · 2026Review
- Bioinformatics-based study on the regulatory network of lipid metabolism-related genes and mechanisms in coronary heart disease.Hereditas · 2025Article
- Quantitative Coronary CT Angiography and Pericoronary Adipose Tissue in Acute Myocardial Infarction: Relationship with Dynamic Myocardial Perfusion SPECT.Diagnostics (Basel, Switzerland) · 2025Article
- Combined prediction value of coronary plaque burden, serum creatinine, MLR and NLR in reinfarction risk after PCI in middle-aged and elderly patients with myocardial infarction.European journal of medical research · 2025Article
- Virtual physiological analysis of non-culprit disease in patients with STEMI and multivessel disease: a substudy of the COMPLETE trial.European heart journal open · 2025Article
- Artificial intelligence quantification and experienced reader computed tomography analysis for differentiating normal from minimally and mildly diseased coronary arteries: an early real-world compatibility study.The international journal of cardiovascular imaging · 2025Article
- Review
- Computed Tomography Angiography Identified High-Risk Coronary Plaques: From Diagnosis to Prognosis and Future Management.Diagnostics (Basel, Switzerland) · 2024Review
- Application of Quantitative Assessment of Coronary Atherosclerosis by Coronary Computed Tomographic Angiography.Korean journal of radiology · 2024Review
- Roadmap on the use of artificial intelligence for imaging of vulnerable atherosclerotic plaque in coronary arteries.Nature reviews. Cardiology · 2024Review
- Uncovering the Potential of Lipid Core Quantification for Predicting Major Adverse Cardiovascular Events.Radiology · 2023Article
- Coronary low-attenuation plaque and high-sensitivity cardiac troponin.Heart (British Cardiac Society) · 2023Article
- Does Coronary Plaque Morphology Matter Beyond Plaque Burden?Current atherosclerosis reports · 2023Review
- Imaging subclinical coronary atherosclerosis to guide lipid management, are we there yet?American journal of preventive cardiology · 2023Review
- Role of cardiac imaging in acute chest pain.The British journal of radiology · 2023Review
- Computed tomography coronary angiography in non-ST-segment elevation myocardial infarction.The British journal of radiology · 2022Review
- First in-human quantitative plaque characterization with ultra-high resolution coronary photon-counting CT angiography.Frontiers in cardiovascular medicine · 2022Article
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Authors and funding
16 authors at 8 institutions in 2 countries.
Funding
Abstract
backgroundIn patients with stable chest pain, computed tomography (CT) plaque burden is an independent predictor of future coronary events.
objectivesThe purpose of this study was to determine whether plaque burden and characteristics can predict subsequent death or myocardial infarction in patients with acute chest pain.
methodsIn a post hoc analysis of a multicenter trial of early coronary CT angiography, the authors performed quantitative plaque analysis to assess the association between primary endpoint of 1-year all-cause death or nonfatal myocardial infarction and the GRACE (Global Registry of Acute Coronary Events) score, presence of obstructive coronary artery disease, and plaque burden in 404 patients with suspected acute coronary syndrome.
resultsFollowing the index event, 25 patients had a primary event that was associated with a higher GRACE score (134 ± 44 vs 113 ± 35; P = 0.012), larger burdens of total (46% [IQR: 43%-50%] vs 36% [IQR: 21%-46%]; P < 0.001), noncalcified (41% [IQR: 37%-%47] vs 33% [IQR: 20%-41%]; P < 0.001), and low-attenuation plaque (4.22% [IQR: 3.3%-5.68%] vs 2.14% [IQR: 0.5%-4.88%]; P < 0.001), but not obstructive coronary artery disease (P = 0.065). Total, noncalcified, and low-attenuation plaque burden were the strongest predictors of future events independent of GRACE score and obstructive coronary artery disease (P ≤ 0.002 for all). Patients with a low-attenuation burden above the median had nearly an 8-fold increased risk of the primary endpoint (HR: 7.80 [95% CI: 2.33-26.0]; P < 0.001), outperforming either a GRACE score of >140 (HR: 3.80 [95% CI :1.45-6.98]; P = 0.004) or obstructive coronary artery disease (HR: 2.07 [95% CI: 0.94-4.53]; P = 0.07).
conclusionsIn patients with suspected acute coronary syndrome, low-attenuation plaque burden is a major predictor of 1-year death or recurrent myocardial infarction. (Rapid Assessment of Potential Ischaemic Heart Disease With CTCA [RAPID-CTCA]; NCT02284191).
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.