Evidence map›Paper›PMID 36356928›Full record

ArticleOsteoarthritis and cartilage2023

3D analysis and grading of calcifications from ex vivo human meniscus.

I Hellberg, V-P Karjalainen, M A J Finnilä, E Jonsson, A Turkiewicz, P Önnerfjord, V Hughes, J Tjörnstrand, M Englund, S Saarakkala

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Osteoarthritis and cartilage, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

I HellbergResearch Unit of Medical Imaging, Physics and Technology, Faculty of Medicine, University of Oulu, Oulu, Finland. Electronic address: iida.hellberg@oulu.fi.
V-P KarjalainenResearch Unit of Medical Imaging, Physics and Technology, Faculty of Medicine, University of Oulu, Oulu, Finland. Electronic address: ville-pauli.karjalainen@oulu.fi.
M A J FinniläResearch Unit of Medical Imaging, Physics and Technology, Faculty of Medicine, University of Oulu, Oulu, Finland. Electronic address: mikko.finnila@oulu.fi.
E JonssonLund University, Faculty of Medicine, Department of Clinical Sciences Lund, Orthopaedics, Clinical Epidemiology Unit, Lund, Sweden; Lund University, Faculty of Medicine, Department of Clinical Sciences Lund, Rheumatology and Molecular Skeletal Biology, Lund, Sweden. Electronic address: elin.jonsson@maxiv.lu.se.
A TurkiewiczLund University, Faculty of Medicine, Department of Clinical Sciences Lund, Orthopaedics, Clinical Epidemiology Unit, Lund, Sweden. Electronic address: aleksandra.turkiewicz@med.lu.se.
P ÖnnerfjordLund University, Faculty of Medicine, Department of Clinical Sciences Lund, Rheumatology and Molecular Skeletal Biology, Lund, Sweden. Electronic address: patrik.onnerfjord@med.lu.se.
V HughesLund University, Faculty of Medicine, Department of Clinical Sciences Lund, Orthopaedics, Clinical Epidemiology Unit, Lund, Sweden. Electronic address: velocity.hughes@med.lu.se.
J TjörnstrandLund University, Skane University Hospital, Department of Clinical Sciences Lund, Orthopaedics, Lund, Sweden. Electronic address: jon.tjornstrand@med.lu.se.
M EnglundLund University, Faculty of Medicine, Department of Clinical Sciences Lund, Orthopaedics, Clinical Epidemiology Unit, Lund, Sweden. Electronic address: martin.englund@med.lu.se.
S SaarakkalaResearch Unit of Medical Imaging, Physics and Technology, Faculty of Medicine, University of Oulu, Oulu, Finland; Department of Diagnostic Radiology, Oulu University Hospital, Oulu, Finland. Electronic address: simo.saarakkala@oulu.fi.
Lund University · SEOulu University Hospital · FIUniversity of Oulu · FI

Funding

European Research Council 336267European Research Council 771121
6 · The paper itself

Abstract

objectiveMeniscal calcifications are associated with the pathogenesis of knee osteoarthritis (OA). We propose a micro-computed tomography (μCT) based 3D analysis of meniscal calcifications ex vivo, including a new grading system.

methodHuman medial and lateral menisci were obtained from 10 patients having total knee replacement for medial compartment OA and 10 deceased donors without knee OA (healthy references). The samples were fixed; one subsection was imaged with μCT, and the adjacent tissue was processed for histological evaluation. Calcifications were examined from the reconstructed 3D μCT images, and a new grading system was developed. To validate the grading system, meniscal calcification volumes (CV

results3D μCT images depict calcifications in every sample, including diminutive calcifications that are not visible in histology. In the new grading system, starting from grade 2, each grade results in a CV

conclusions3D μCT grading of meniscal calcifications is feasible. Interestingly, it seems that there are two patterns of degeneration in the menisci of our sample set: 1) with diminutive calcifications (calcification grades 1-2), and 2) with large to widespread calcifications (calcification grades 3-5).

Indexed as

CalcinosisMeniscusOsteoarthritis, KneeHumansMagnetic Resonance ImagingMenisci, TibialX-Ray MicrotomographyCalcification gradingMeniscal calcificationMicro-computed tomographyVolumetric analysis

Identifiers

PMID36356928
PMCPMC7614369
OpenAlexW4308448155

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.